DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and UST4r

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_599206.2	Gene:	UST4r / 171397	RGDID:	620976	Length:	552	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	137/573 - (23%)
Similarity:	247/573 - (43%)	Gaps:	63/573 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYV-------FTAATVTHRC--------SVEECD 79
            :|..:|..||||:       |.|:|....||..|       ||||..:|||        :|.:.|
  Rat     6 LLNQVGGLGRFQI-------LQMVFVVFTSVIVVPHIIIENFTAAIPSHRCWVPILDNVTVSDND 63

  Fly    80 LPGSNYYEPHTNWSIPKNGK-DLDSCNRYTNSELPQWNHSVDICSADHFTK----NKEAC----A 135
            ....| .:.....|||.:.. .||.|.|:..   ||| |.:|:  .|.|:.    :.|.|    .
  Rat    64 SRILN-QDKLLKISIPLDSHLRLDKCRRFAQ---PQW-HLLDL--NDTFSSITEPDTEPCVDGWV 121

  Fly   136 HNEFVFRDDEVTISNDFGIFCDDE-----WKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIAL 195
            ::...|....||   ::.:.|:.:     .|||.:     :|.|.|..:.|.::||:||.|.:..
  Rat   122 YDRSNFHSTTVT---EWNLVCESQALNSVTKLSFM-----IGAFIGGIVNGLLSDRFGRKFILKY 178

  Fly   196 GGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAV 260
            ..:..|:......|:|:...:....||..|:...:.....::..|...||...:...:.:...:.
  Rat   179 ALLQMAITETCAGFAPNLFIYCSLRFLAGMSLEPITVNINLLMFEWTSPKFLTMVTVLGSCAGSF 243

  Fly   261 GEVLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVN-K 324
            |.::||..|..|.:|..|......|....|.....|.||.|||:...|.::....|::.||:| .
  Rat   244 GGMILAGLAFQFQNWHHLQLAMSVPIFFFLILTRWLSESARWLIVINKPQKGLKELKKVAHINGM 308

  Fly   325 RELPESVLDKLVLANRDKLQQSSESRFPIREAFKN--FKWRIANCSLCWIVHVLVYYGLSLNVVL 387
            ::..:::..::|..:..|..::::.|...|:.|..  .:.:|...|...::.:|...|:::::..
  Rat   309 KKSGDNITMEVVRTSMKKELEAAKMRPSPRDLFHTPILRKQIYILSFIRLLFILSGVGVAIHLQH 373

  Fly   388 LDGDKYNNFAYI-ALVEIPGFFMPLL---IMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQ 448
            |.    ||...: .|:.:......::   :::..|||.:...:|...|:..:..||...:...|:
  Rat   374 LS----NNIELLQILISVSSILFSVIGHFVLNHIGRRITQMVIMFLRGISILTAIFAPQEMETLR 434

  Fly   449 LVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAM 513
            .::.::.:.....|:......|:|:.||.||.:......|.|..|..|||...:||.|..|.|.:
  Rat   435 FIMAMMAEGLAALSYAANSLHANELLPTTLRATARGVIGMFGNIGFFLAPLCMMLASYSPNLPWI 499

  Fly   514 LFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKSKDLDLVVTATQ 566
            .:.|.||:||.:.|..|||.|..||....:.:....:.:.:.|: |.::..|:
  Rat   500 FYGGFAILSGFIVLLLPETKNNPLPDCTHDVENDWKESRQEMKE-DPIIKVTR 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	133/540 (25%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	89/395 (23%)
UST4r	NP_599206.2	MFS_OAT	109..516	CDD:340932	92/418 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.940