DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC22A and SLC22A31

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001371692.1	Gene:	SLC22A31 / 146429	HGNCID:	27091	Length:	446	Species:	Homo sapiens

Alignment Length:	427	Identity:	111/427 - (25%)
Similarity:	178/427 - (41%)	Gaps:	45/427 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 ISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPS 212
            :|.::.:.|.|.||:.:....:.||...|..|.|...||:||........:|...||...:.:.|
Human     5 LSQNWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAAS 69

  Fly   213 YGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFHDWRI 277
            :...||...|...|.:......::..:||..|..|:.......:|..||.:||...|....|||:
Human    70 FPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQDWRL 134

  Fly   278 LLRITYGPSLILLAYFW----ILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKLVLA 338
            |..:....|.:|| .||    :.|||..|||:.|:..||:.||.|.|..:.....:|.|::..||
Human   135 LQGLGALMSGLLL-LFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDSSLEENSLA 198

  Fly   339 NRDKL--QQSSESRF--PIREAFKNFKWRIANCSLCWIVHVLVYYGLSLNV-VLLDGDKYNNFAY 398
            ....:  .:|.:.|:  |:........||               .||.|.. .|:.|....:|..
Human   199 TELTMLSARSPQPRYHSPLGLLRTRVTWR---------------NGLILGFSSLVGGGIRASFRR 248

  Fly   399 IALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCC-------IGTIFTGADQPVL--------- 447
            ....::|.|::|..:  ..|...:....:|.:..||       :||:.||....:|
Human   249 SLAPQVPTFYLPYFL--EAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPG 311

  Fly   448 QLVLFL--VGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANA 510
            ..||||  :|.|...|...:...||:|::||.:|.:.|......|..|....|...|..:.....
Human   312 WTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFL 376

  Fly   511 PAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAI 547
            ..::||..|:::.|..|..||:.:..||.::|:||.:
Human   377 QQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRL 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	108/418 (26%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	104/408 (25%)
SLC22A31	NP_001371692.1	MFS	9..383	CDD:421695	99/391 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010