Protein Alignment SLC22A and SLC22A12

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: XP_006718493.1
• Gene: SLC22A12 / 116085
• HGNCID: 17989
• Length: 578
• Species: Homo sapiens
• Alignment Length: 584
• Identity: 146/584 - (25%)
• Similarity: 255/584 - (43%)
• Gaps: 59/584 - (10%)

  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRC-------SVEECDLPGSNYYE 87
            :|..:|..||||::..:.:.:.:|:....|:...|:||..:|||       |..:..:.||...|
Human     6 LLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPE 70

  Fly    88 PHTNWSIPKN-GKDLDSCNRYTNSELPQWNHSVDICSADHFTK-NKEAC----AHNEFVFRDDEV 146
            .....|||.. .:....|.|:..   |||.......:|..::: :.|.|    .::..:|..
Human    71 ALLAISIPPGPNQRPHQCRRFRQ---PQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTS--- 129

  Fly   147 TISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSP 211
            ||...:.:.||......|..:|...|...|....|..:||:||...:....:..||:|...:|:|
Human   130 TIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAP 194

  Fly   212 SYGWFLVFEFL-------DNMTSSTLY--------------STCFVIGI----ELVGPKRRVLAC 251
            ::..:.:|.||       ..|.:.||.              |....:|:    |....:.|.|..
Human   195 AFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHAGSRAEPLGLLAVMEWTAARARPLVM 259

  Fly   252 SVITVFYAVGEVLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNIL 316
            ::.::.::.|..|.|..|....||.:|..:...|..:...|.|.|.||.||||:.|:.:.....|
Human   260 TLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQEL 324

  Fly   317 RRAAHVNKRELPESVL--DKLVLANRDKLQQSSES-------RFPIREAFKNFKWRIANCSLCWI 372
            .|.|.:|.:...:..|  :.|:.|.|::|......       |.|      ..::|....:|||.
Human   325 WRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMP------GLRFRTCISTLCWF 383

  Fly   373 VHVLVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGT 437
            .....::||:|::..|..:.:....:|.:|:||.....||::...|||.:|...:|.:|||.:..
Human   384 AFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILAN 448

  Fly   438 IFTGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPL 502
            .....:...|:..|.::|...:.|:|..:..::||::||.||.:.:....|..|.|::|.|...|
Human   449 TLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRL 513

  Fly   503 LAKYYANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKSKDLDLVVTATQ 566
            |..:....|.:::....::|||..|..|||.::.||.|:|:.....|||.:.....:.|:.:||
Human   514 LGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQ 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	104/427 (24%)
SLC22A12	XP_006718493.1	MFS_OAT	109..541	CDD:340932	106/440 (24%)