Protein Alignment SLC22A and SLC22A9

DIOPT Version :9

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_543142.2
• Gene: SLC22A9 / 114571
• HGNCID: 16261
• Length: 553
• Species: Homo sapiens
• Alignment Length: 592
• Identity: 152/592 - (25%)
• Similarity: 239/592 - (40%)
• Gaps: 100/592 - (16%)

  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSV-TYV------FTAATVTHRCSVEECDL------- 80
            :|.|.|...|||:       |..:|.::|:| ||:      |||....|||.|...|.
Human     6 LLGHAGDLWRFQI-------LQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDND 63

  Fly    81 PGSNYYEPHTNWSIPKNGKDLDS------CNRYTNSELPQW----------NHSVDICSADHFTK 129
            .|:...:.....|||     |||      |.|:.:   |||          |.|    .||
Human    64 TGALSQDALLRISIP-----LDSNMRPEKCRRFVH---PQWQLLHLNGTFPNTS----DAD---- 112

  Fly   130 NKEACAHNEFVFRDDEV----TISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRS 190
             .|.|. :.:|:  |.:    ||..::.:.||.:...|:...:...|...|..:||.::||:||.
Human   113 -MEPCV-DGWVY--DRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRR 173

  Fly   191 FSIALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVIT 255
            |.:....:..|::|...:.:|::..:....||..:.:.:|.:...::..|....:.:.:..::..
Human   174 FVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGM 238

  Fly   256 VFYAVGEVLLAMSAKAFHDWRILLRITYGP-SLILLAYFWILPESVRWLLSQGKEERAKNILRRA 319
            ....:..:.||..|.|..||.||..:...| .:|.|...|:| ||.|||:...|.|.....||:|
Human   239 CPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLL-ESARWLIINNKPEEGLKELRKA 302

  Fly   320 AH----VNKR-----ELPESVLDK-LVLANRDKLQQSSESRFPIREAFKNFKWRIANCSLCWIVH 374
            ||    .|.|     |:.:|.:.| |..|.:.|.........|      |...||:..|.....:
Human   303 AHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMP------NICKRISLLSFTRFAN 361

  Fly   375 VLVYYGLSLNVVLLDGDKYNNFAYI-----ALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCC 434
            .:.|:||:|:|..|.    ||...:     |::.:.....| ..:....||.|...||....:|.
Human   362 FMAYFGLNLHVQHLG----NNVFLLQTLFGAVILLANCVAP-WALKYMNRRASQMLLMFLLAICL 421

  Fly   435 IGTIFTGADQPVLQLVLFLVGKLTITASFQVLYF-FASEIYPTNLRNSLLSFCSMMGRFGSMLAP 498
            :..||...:...|:.||..:| |..:|....|.| ..:|:.||.:|...:...:........|||
Human   422 LAIIFVPQEMQTLREVLATLG-LGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAP 485

  Fly   499 QTPLLAKYYANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKS----KDLD 559
            ...:|:.|....|.:::.....:||...|..|||.|..|..|:|:.     |.:.|.    |..|
Human   486 LMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDE-----KNERKDPREPKQED 545

  Fly   560 LVVTATQ 566
            ..|..||
Human   546 PRVEVTQ 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	141/555 (25%)
		MFS	146..530	CDD:119392	98/404 (24%)
SLC22A9	NP_543142.2	Sugar_tr	11..527	CDD:331684	141/555 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	528..553		8/30 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153762
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940