Protein Alignment SLC22A and SLC22A7

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: XP_011512558.1
• Gene: SLC22A7 / 10864
• HGNCID: 10971
• Length: 610
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 155/615 - (25%)
• Similarity: 251/615 - (40%)
• Gaps: 125/615 - (20%)

  Fly    28 DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTN- 91
            :.:|:.:|.||.|||....|:.||.:...:..:..:|.||...|||:     |||:.....|.:
Human     4 EELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCA-----LPGAPANFSHQDV 63

  Fly    92 W---SIPKN-GKDLDSCNRYT------NSELPQWNHSVDICSADHFTKNKEACA------HNEFV 140
            |   .:|:. ...|.||.|:.      |:.|.:...|......:..|   ..|:      |:||
Human    64 WLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPAT---VPCSQGWEYDHSEF- 124

  Fly   141 FRDDEVTISNDFGIF-------C-------------------------------DDEWKLSMVGT 167
              ...:...:..||:       |                               ...|:.|:.|.
Human   125 --SSTIATESQVGIYIIHLEVECRWRQSPWEAAGRGLPWEEAEAAGLGRDKVSYSPSWRESLGGL 187

  Fly   168 INNL---------------GQFF--GIPIG----GFVADRYGRSFSIALGGILGAVLGVIRSFSP 211
            ::.:               ..||  |:.:|    |:::||:||...:.:..:...|||:..:.|.
Human   188 LSGMEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASV 252

  Fly   212 SYGWFLVFEFLDNMTSSTLYSTCFVI------GIELVGPKRRVLACSVITVFYAVGEVLLAMSAK 270
            ||   ::|.....:|.|.|.....::      .:|.:..:.|.:|..:.:.|:..|.:|||:...
Human   253 SY---VMFAITRTLTGSALAGFTIIVMPLGEAELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGY 314

  Fly   271 AFHDWR-ILLRITY--GPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVL 332
            ...||| :||.:|.  .|.::.|   |.:|||.||||:||..:.|...|...|.:|.|.:.|
Human   315 LIRDWRWLLLAVTLPCAPGILSL---WWVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCE--- 373

  Fly   333 DKLVLANRDKLQQSSESRFPIREAFKN-------FKW-RIANCSLC----WIVHVLVYYGLSLNV 385
                    |...|.:.|:....|....       |:. |:.:.|||    |......||||||:|
Human   374 --------DSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDV 430

  Fly   386 VLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLV 450
            ..|..:.|........||:|...:..|.:...|||.:..|.:|.:.|.....:...:|......|
Human   431 SGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTV 495

  Fly   451 LFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLF 515
            |.::||....|:|...|.|.||:|||.||.:.:...:::||.|..|||...||...:.:.|.:.:
Human   496 LAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTY 560

  Fly   516 AGAAIVSGLLTLFFPETTNVVLPTTVQEAD 545
            .|.|:::....|..|||....||.|:|:.:
Human   561 GGIALLAAGTALLLPETRQAQLPETIQDVE 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	117/473 (25%)
SLC22A7	XP_011512558.1	MFS	106..563	CDD:475125	116/479 (24%)