Protein Alignment SLC22A and slc22a8

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: XP_002937554.2
• Gene: slc22a8 / 100490266
• XenbaseID: XB-GENE-22061134
• Length: 556
• Species: Xenopus tropicalis
• Alignment Length: 563
• Identity: 157/563 - (27%)
• Similarity: 258/563 - (45%)
• Gaps: 60/563 - (10%)

  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEP-HTNWS 93
            :|:..|..||||:...:|:|.|::..|..::...|:||...|:|...:.....::..|. :...|
 Frog     6 LLERTGGMGRFQITQVVLLCFPILLMASHNLLQNFSAAIPDHKCKANDTGYQSNSTDETGYERLS 70

  Fly    94 IP--KNGKDLDSCNRY---------TNSELPQWNHSVDIC----------SADHFTKNKEACAHN 137
            .|  .||:. |.|..|         :||   .||:|.::.          |.|.|:.
 Frog    71 APLDANGQP-DRCLEYVEIQWRMVGSNS---TWNNSSELATRPCTIGWEYSKDEFSS-------- 123

  Fly   138 EFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAV 202
                     ||..::.:.|..:.:..:..:|...|...|..|.|.::|||||...:.......||
 Frog   124 ---------TIITEWDLVCGRKTRRQLAQSIYMGGVLVGAIILGGLSDRYGRRALLIWSYFQLAV 179

  Fly   203 LGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAM 267
            .||..:|||:|..:.:|.||..|..|.:......:.:|.|..:.|.:..::....|..|::|||.
 Frog   180 SGVCAAFSPNYLSYCIFRFLTGMALSGIGLNTTALIVEWVPTRVRTVTGTLAGFSYTAGQLLLAG 244

  Fly   268 SAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVN-KRELPESV 331
            .|....|||.|......|..|...|.|..|||.|||:..||.|:|...:|:.|::| |:|..|.:
 Frog   245 LAYGMRDWRWLQLCVSLPFFIYFLYAWWFPESARWLVLSGKPEKAVKEIRKVANLNGKKEEGEKI 309

  Fly   332 LDKLVLANRDKLQQSSESRFPIREAFKNFKWRIANC--SLCWIVHVLVYYGLSLNVVLLDGDKYN 394
            ..:.:.:...|...|::|.:.:.:..:....|..:|  ||.|......||||:     :|..|:|
 Frog   310 TLESLKSEMIKELASAKSSYSVIDLVRTNTIRRISCALSLVWFSTSFAYYGLA-----MDLQKFN 369

  Fly   395 NFAYI-----ALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLV 454
            ...|:     ..|:.|...:....|...||:::....::..|:..|..||...:...::..|.:.
 Frog   370 VSIYLIQVIFGAVDFPAKLVSATAMIYVGRKFTQFMSLILGGIAIIANIFVPNELQTVRTSLAVF 434

  Fly   455 GKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAA 519
            ||..:.|||..::.:.:|:|||.:|.|.|..||.|.|.|.::||...:|.:.|...|.:::.||.
 Frog   435 GKGCLAASFSCIFLYTTELYPTVIRQSGLGMCSTMARIGGIVAPLVKILGELYPFVPLLIYGGAP 499

  Fly   520 IVSGLLTLFFPETTNVVLPTTVQEADAIGV---KKQSKSKDLD 559
            |:|||...|.|||.|..||.|::|.:. |:   ||:.:..::|
 Frog   500 IISGLCVFFLPETVNKPLPDTIEEVEK-GINAPKKEIEKNEMD 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	114/401 (28%)
slc22a8	XP_002937554.2	MFS_SLC22A6_OAT1_like	105..510	CDD:341004	117/426 (27%)