DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and slc22a16

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_002936981.2	Gene:	slc22a16 / 100488673	XenbaseID:	XB-GENE-961385	Length:	567	Species:	Xenopus tropicalis

Alignment Length:	560	Identity:	151/560 - (26%)
Similarity:	252/560 - (45%)	Gaps:	42/560 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRC----SVEECDLPGSNYYE 87
            ::.:..::|.|||||.:|:.......:...:..:..||.|.|....|    ::....||.::...
Frog     1 MERLFDYVGHFGRFQALIYFSSAFQAISCGIHYLASVFIAITPKFICRAPENISSVLLPNASTLR 65

  Fly    88 PHTNWSI--PK--------NGK--DLDSCNRYTNSELPQWNHSVD------ICSADHFTKNKEAC 134
            ....|.:  ||        ||.  :|:.|:|:.........:|.|      .||..::..|...
Frog    66 LEDVWELWTPKDYLVVKQENGDIWELNQCSRFKRENTSYLTYSYDGNKTLFSCSNGYYYDNTNL- 129

  Fly   135 AHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGIL 199
                      |.:|..|:.:.|:.||...::......|...|..|.|.:|||.||...:.|....
Frog   130 ----------ESSIVTDWHLVCEREWLAKLIQPTFMFGVLIGAVIFGDIADRVGRRLILWLTSTG 184

  Fly   200 GAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVL 264
            ..:.|:..:|:..|..|::..||..|.||..|...||...|.||.|.|..|...:..|:|||.::
Frog   185 QFLFGIAVAFTFDYYSFVIVRFLLAMVSSGYYVVVFVYVTEYVGIKARSWASMHVHAFFAVGVMI 249

  Fly   265 LAMSAKAFHDW---RILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRE 326
            :::.......|   :|:|.:|..|.::..   |:|||:..||.||||.:..:.::......||..
Frog   250 VSLVGFLVRTWWMYQIILSLTTLPFVLCC---WMLPETPFWLYSQGKHKEVEKLIGTIEKWNKIS 311

  Fly   327 LPESVLDKLVLANRDKLQQSSESRFPIREAFKN--FKWRIANCSLCWIVHVLVYYGLSLNVVLLD 389
            .|..:.:...:....|.:..:..:..:.:.|.|  |..|.....|.|....|.||..:||.|.|.
Frog   312 TPCKLSELCSVQETQKTEMDTLKKHSVLDLFYNWSFARRTVTVWLIWFTGSLGYYVFALNSVNLG 376

  Fly   390 GDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLV 454
            |::|.|....:.||||.:.:....||:.|||.:|...::.|.:.|...:....|...:.:.:.:.
Frog   377 GNEYLNLFLTSAVEIPSYIVACFGMDKIGRRNTLAPFLILSAVICGIIMLIPQDHSTVTIAMSMG 441

  Fly   455 GKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAA 519
            ||.:|..:|.::|.:.:|:|||.:|:..:...|||.|.||::||....|...:...|.||....|
Frog   442 GKFSIAVAFGLIYLYTAELYPTIVRSLAVGSGSMMCRIGSVVAPFCVYLTDVWIFMPQMLVGIMA 506

  Fly   520 IVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQ-SKSKDL 558
            .::|:|||..|||..|.|.:|::||..:|...: :|.|.:
Frog   507 FLTGVLTLKLPETLGVPLTSTIEEAAEMGTNNRITKRKSI 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	145/531 (27%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	112/388 (29%)
slc22a16	XP_002936981.2	MFS_SLC22A16_CT2	111..517	CDD:340933	116/419 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010