Protein Alignment SLC22A and slc22a6

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: XP_002937540.1
• Gene: slc22a6 / 100487511
• XenbaseID: XB-GENE-5842250
• Length: 552
• Species: Xenopus tropicalis
• Alignment Length: 551
• Identity: 149/551 - (27%)
• Similarity: 249/551 - (45%)
• Gaps: 42/551 - (7%)

  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRC----SVEECDLPGSNYYEPHT 90
            ||:.:|..||:|:|..:|:.||:...|..::...||||...|||    |.||     :|:..|..
 Frog     6 ILESIGGMGRYQVIHVVLLSLPVFMLASHNLMQNFTAAIPRHRCQINGSFEE-----TNFTGPWL 65

  Fly    91 NWSIP-KNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKN-----KEACA------HNEFVFRD 143
            ...:| |...:...|.|||.   ||::     ...|:||:|     .|.|.      |:||.
 Frog    66 RALVPMKPTGEFSKCLRYTT---PQYH-----LLMDNFTQNVDELETETCVDGWVYDHSEFA--- 119

  Fly   144 DEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRS 208
              .||...:.:.|:......:..:|...|...|..:.|.::|::||........:..:|.|:..:
 Frog   120 --STIITQWDLVCNHRRMRQVAQSIYMAGVLVGSVVFGGLSDKFGRRPLNIWSNLQMSVTGICAA 182

  Fly   209 FSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAKAFH 273
            |||:|.|:.:|.||.....|.:....:.:.:|.:....|....:.....|.:|:::|...|....
 Frog   183 FSPNYIWYCIFRFLTGTALSGIVLNSYSLIVEWIPTGNRAFTSTATGYCYTMGQLVLVGLAFMIR 247

  Fly   274 DWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVN-KRELPESV-LDKLV 336
            ||..|......|......|.|.:|||.|||:..||.|.|...|::.|.:| |:|..|.: ::.|.
 Frog   248 DWHWLQLAASLPFFFYFLYSWWIPESGRWLVLSGKPEVACKALKKVAKINGKKEAGEKLTVEVLK 312

  Fly   337 LANRDKLQQSSESRFPIREAFKN-FKWRIANCSLC-WIVHVLVYYGLSLNVVLLDGDKYNNFAYI 399
            .:.:.::..|..|.:.:.:..:. ...||:.|..| |......||||:|::.......|......
 Frog   313 SSMQREISASKHSTYSVLDLVRTPVVRRISFCISCTWFSTSFAYYGLALDLQSFGVSIYIIQIIF 377

  Fly   400 ALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITASFQ 464
            ..|:||..|....:|...|||......::.:|:..:..|....|...::..:.:.||..:.|||.
 Frog   378 GTVDIPAKFFSYFVMTYIGRRVLQALTLILAGIAILVNICVPQDYQTVRTSMAVFGKGCLAASFN 442

  Fly   465 VLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAAIVSGLLTLFF 529
            .|:.:..|:|||.:|.|.:...:||.|.|.::||...:....|.:.|.::|....|:||:...|.
 Frog   443 CLFLYTGELYPTVIRQSGMGLGTMMARLGGIIAPLAQMTGDIYHSLPLIIFGCLPILSGIAGCFL 507

  Fly   530 PETTNVVLPTTVQEADAIGVKKQSKSKDLDL 560
            |||..|.||.|:::.::    ...|.|:::|
 Frog   508 PETLGVPLPETIEDVES----SDKKQKNVEL 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	102/397 (26%)
slc22a6	XP_002937540.1	MFS_SLC22A6_OAT1_like	102..508	CDD:341004	104/410 (25%)