Protein Alignment SLC22A and sv2a

DIOPT Version :10

• Sequence 1: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: XP_012825002.1
• Gene: sv2a / 100379721
• XenbaseID: XB-GENE-968429
• Length: 729
• Species: Xenopus tropicalis
• Alignment Length: 692
• Identity: 134/692 - (19%)
• Similarity: 210/692 - (30%)
• Gaps: 267/692 - (38%)

  Fly    20 KDSEDVT--LDAILKHLGQFGRFQLIIFLLICLPMMFHA--MFSVTYVFTAATVTHRCSVEECDL 80
            ||.|::.  .:.||:..|. ||||..::.::.|.:|...  :|.|.:|..:|
 Frog   130 KDKEELAQQYEVILQECGH-GRFQWTLYFVLGLALMADGVEIFVVGFVLPSA------------- 180

  Fly    81 PGSNYYEPHTNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDE 145
                                                 ..|:|.:|   .||
 Frog   181 -------------------------------------EKDMCLSD---SNK-------------- 191

  Fly   146 VTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFS 210
                             .|:|.|..||...|..:.|.:|||.||...:.:...:.:|.....||.
 Frog   192 -----------------GMLGLIVYLGMMVGAFLWGGMADRIGRRQCLLISLSVNSVFAFFSSFV 239

  Fly   211 PSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAM-------- 267
            ..||.||....|..:.........|....|.:..::|....|.:.:|:.:|.:..:.
 Frog   240 QGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPH 304

  Fly   268 --------SAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNK 324
                    ||..||.||:.:.:...||:..:.....:|||.|:.|..||.:.|..:|::....|.
 Frog   305 YGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNM 369

  Fly   325 REL--PESVL-----------DKLVLANRD----------KLQQSSESRFPIREAFKNF------ 360
            |..  ||.|.           |:||....|          ||...|:      |.:.||
 Frog   370 RAKGHPERVFSVTQIKTIKQDDELVEIQSDTGALHRRWMIKLLNLSQ------EVWANFHQCFAP 428

  Fly   361 KWRIANCSL--CWIVHVLVYYGLSL----------NVVLLDGDKY------NNF----------- 396
            ::|.....:  .|......||||::          |:......||      |||
 Frog   429 EYRRITLMMMAVWFTMSFSYYGLTVWFPDMIKHLQNIDYASRTKYFHNESVNNFNFNFTLENQVH 493

  Fly   397 ----------------------------------------------------------------- 396
                                                                             
 Frog   494 RKGEYHNDKFIGLKLKSVIFEDSLFTDCYFEDITSSNTFFKNCSFIRTMFYNTDLFDYKFINSKF 558

  Fly   397 ----------------------AYI--------ALVEIPGFFMPLLIMDRFGRRYSLCGLMLASG 431
                                  ||:        .|..:||..:..|:||:.||...|.|..:.|.
 Frog   559 TNSTFLHSKEGCQLDFSDDINNAYMIYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSC 623

  Fly   432 LCCIGTIFTGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSML 496
            :.|. .:|.|..:..:..:|.|.|.::| ||:..|.....|:||::.|.:...|.:.:.:..::|
 Frog   624 ISCF-FLFFGNSESAMIALLCLFGGVSI-ASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVL 686

  Fly   497 APQTPLLAKYYANAPAMLFAGAAI-VSGLLTLFFPETTNVVL 537
            ...........|.|..:|.|.||: |...|.|..|||...||
 Frog   687 GISIFTSFVGVAKAVPILLASAALAVGSFLALKLPETRGQVL 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	108/563 (19%)
sv2a	XP_012825002.1	synapt_SV2	1..729	CDD:130366	134/692 (19%)