DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A and slc22a7b.2

DIOPT Version :9

Sequence 1:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_001337343.1	Gene:	slc22a7b.2 / 100001838	ZFINID:	ZDB-GENE-030131-9391	Length:	556	Species:	Danio rerio

Alignment Length:	552	Identity:	138/552 - (25%)
Similarity:	249/552 - (45%)	Gaps:	61/552 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYV---FTAATVTHRCSVEECDLPG---SNYYEP 88
            :|..|..|||||.::   :|:..:........::   |.||..:|.|::...|:.|   :...|.
Zfish     6 LLSELNGFGRFQKMV---LCINFLGRFSLGCHFLLGNFIAAIPSHHCNISSLDVDGVFENLSQEE 67

  Fly    89 HTNWSIP--KNGKDLDSCNRYTNSELPQWNHSVDICSAD-----------HFTKNKEACAHNEFV 140
            .....:|  ::|... ||:.:::   ||:...::..|:.           ||.       ::.|:
Zfish    68 RLTVGVPAQEDGTPA-SCHMFSH---PQFQLLINSSSSSDLPVVECQNGWHFD-------NSTFI 121

  Fly   141 FRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGV 205
                 .|::..:.:.||......:..||..||..||....|.::..:||...:.:..|||...|:
Zfish   122 -----STLATQWDLVCDKRALGKLTTTIFFLGVMFGAAAFGSLSAMFGRKPMLLVSYILGMGFGL 181

  Fly   206 IRSFSPSYGWFLVFEFLD--NMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMS 268
            ....|.|...|.|..|..  .:|.|.:.||  |:.:|.|..:.|.|...:.::.:..|.:...:.
Zfish   182 CSVLSSSLVMFAVLRFFSGFTITGSVIIST--VLNVEWVSIEHRKLVGVIDSLAWTFGFMGFPVI 244

  Fly   269 AKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVN-KREL----- 327
            |....|||.|......|::|.:..:|.:|||.|||:..||.::|...|::.|.:| |:|:
Zfish   245 AYFIRDWRWLTVAISLPNVISIITWWWVPESARWLIVNGKADKAHYYLKKCAAMNHKKEVTARIK 309

  Fly   328 PESVLDKLVLANRDKLQQSSESRFPIREAFKNFKWRIAN--CSLCWIVHVLVYYGLSLNVVLLDG 390
            ||. |.|:::.:|      ...::...:..:..|.|..:  ..:.|.....|.||:|.|:.....
Zfish   310 PED-LSKIIVTDR------GSRKYSYLDLVRTPKMRRLSLLTGITWFSVATVAYGISFNITGFGL 367

  Fly   391 DKY-NNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLV 454
            :.| ..|.|.| :|||..|....::|:|||..:..|.:|..|:..|..||...::.|::.|:.::
Zfish   368 NMYLTQFVYGA-IEIPAKFCIYYLLDKFGRHVTQAGSLLFVGISFIINIFIPKEKTVIRTVIAVL 431

  Fly   455 GKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFAGAA 519
            ||.....||..:..:.||:|||.:|.:.:.:.|.:.|||..:||...|....::....::....|
Zfish   432 GKGCSATSFGTVILYTSELYPTVVRQNGMGYTSFIARFGVSVAPLILLSNDVWSYFSQVILCFLA 496

  Fly   520 IVSGLLTLFFPETTNVVLPTTVQEADAIGVKK 551
            :.:..:....|||:...||.|:.:.:  |::|
Zfish   497 LSAAFVAYQLPETSGKCLPETIDDIE--GIRK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	133/534 (25%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	104/394 (26%)
slc22a7b.2	XP_001337343.1	2A0119	12..517	CDD:273328	133/533 (25%)
slc22a7b.2	XP_001337343.1	MFS	140..504	CDD:119392	101/373 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010