DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mub and igf2bp3

DIOPT Version :9

Sequence 1:	NP_001246875.1	Gene:	mub / 40436	FlyBaseID:	FBgn0262737	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_001017139.1	Gene:	igf2bp3 / 549893	XenbaseID:	XB-GENE-483018	Length:	594	Species:	Xenopus tropicalis

Alignment Length:	445	Identity:	96/445 - (21%)
Similarity:	170/445 - (38%)	Gaps:	106/445 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SAGGASIKHEDPSVTLTIRLIMQGKEVGSIIGKKGEIVNRFREESGAKINI---SDGSCPERIVT 70
            |.|.|:  ...|...:.:|:::..:.||:||||:|..:....:::.:||:|   .:....|:.:|
Frog   193 SPGAAA--RPKPQSEVPLRMLVPTQFVGAIIGKEGATIRNITKQTQSKIDIHRKENAGAAEKPIT 255

  Fly    71 VSGTTNAIFSAFTLITK---------KFEEWCSQFNDVGKVGKTQIPIRLIVPASQCGSLIGKSG 126
            :..|.....:|..:|.:         ||.|              :||::::...:..|.||||.|
Frog   256 IHSTPEGCSAACKIIMEIMQKEAQDTKFTE--------------EIPLKILAHNNFVGRLIGKEG 306

  Fly   127 SKIKEIRQTTGCSIQVA--SEMLPNSTERAVTLSGSAEQITQCIYQICLVMLES----------- 178
            ..:|:|.|.|...|.::  .::...:.||.:|:.||.|...:...:|...:.||
Frog   307 RNLKKIEQDTDTKITISPLQDLTLYNPERTITVKGSIEACAKAEEEIMKKIRESYENDIAAMNLQ 371

  Fly   179 ---------------PPRGATIPYRPKPQVTGPVILANGQAFTIQGNYAVPTQETCPVFPLALAT 228
                           ||..:.:| .|...|..|....:...|..|     |..||..:|..|||.
Frog   372 AHLIPGLNLNALGLFPPSSSGMP-PPSVGVPSPTTSTSYPPFGQQ-----PESETVHLFIPALAV 430

  Fly   229 GGLHAGISGLADPLLKGAHLQGAIPAHHHHLQQMPDV---------AKNPLASLAALGLAGMNPA 284
            |.:                    |.....|::|:...         |:.|.|.|..:.:.|...|
Frog   431 GAI--------------------IGKQGQHIKQLSRFAGASIKIAPAEGPDAKLRMVIITGPPEA 475

  Fly   285 ---STGGI------NHTANPANRAQQQQHEMTVSNDLIGCIIGKGGTKIAEIRQISGAMIRISNC 340
               :.|.|      .:...|....:.:.| :.|.:...|.:|||||..:.|::.::.|.:.:..
Frog   476 QFKAQGRIYGKLKEENFFGPKEEVKLEAH-IKVPSYAAGRVIGKGGKTVNELQNLTSAEVVVPR- 538

  Fly   341 EEREGGNTDRTITISGNPDSVALAQYLINMSVELQKANLLEQAQSQQNGGAAAAP 395
            ::....|....:.|:|:..:..|||..|...:    |.:..|.|.||....:..|
Frog   539 DQTPDENDQVVVKITGHFYASQLAQRKIQEIL----AQVRRQQQQQQKTAQSGQP 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mub	NP_001246875.1	PCBP_like_KH	25..86	CDD:239089	15/63 (24%)
		PCBP_like_KH	109..172	CDD:239089	17/64 (27%)
		KH-I	305..368	CDD:238053	15/62 (24%)
igf2bp3	NP_001017139.1	RRM1_IGF2BP3	1..77	CDD:241071
		RRM2_IGF2BP3	81..156	CDD:241074
		KH-I	208..271	CDD:238053	15/62 (24%)
		KH-I	289..354	CDD:238053	17/64 (27%)
		KH-I	420..483	CDD:238053	16/82 (20%)
		KH-I	502..567	CDD:238053	16/66 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394765at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010