DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mub and NOVA1

DIOPT Version :9

Sequence 1:	NP_001246875.1	Gene:	mub / 40436	FlyBaseID:	FBgn0262737	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_002506.2	Gene:	NOVA1 / 4857	HGNCID:	7886	Length:	507	Species:	Homo sapiens

Alignment Length:	485	Identity:	118/485 - (24%)
Similarity:	186/485 - (38%)	Gaps:	150/485 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 IRLIMQGKEVGSIIGKKGEIVNRFREESGAKINISDG-----SCPERIVTVSGTTNAIFSAFTLI 85
            :::::.....||||||.|:.:.:.::|:||.|.:|..     ...||:..:.||..|:.:....|
Human    52 LKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLIQGTVEALNAVHGFI 116

  Fly    86 TKKFEEWCSQFNDVGKVGKTQ-------------------IP---------------------IR 110
            .:|..|...      .|.||:                   :|                     ::
Human   117 AEKIREMPQ------NVAKTEPVSILQPQTTVNPDRIKQTLPSSPTTTKSSPSDPMTTSRANQVK 175

  Fly   111 LIVPASQCGSLIGKSGSKIKEIRQTTGCSIQVASEMLP---NSTERAVTLSGSAEQITQCIYQIC 172
            :|||.|..|.:|||.|:.:|.:.:.:|..:|::.:  |   |..||.||:||..||..:.:..|.
Human   176 IIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQK--PDGINLQERVVTVSGEPEQNRKAVELII 238

  Fly   173 LVMLESPPRGA--TIPYRPKPQVTGPVILANGQAFTIQGNYAVPTQETCPVFPLALATGGL--HA 233
            ..:.|.|..|:  .|.|   ..|||||..:|..        ..|...|..|.|.|.|..||  ||
Human   239 QKIQEDPQSGSCLNISY---ANVTGPVANSNPT--------GSPYANTAEVLPTAAAAAGLLGHA 292

  Fly   234 GISGLA--DPLLKG--------------------------------AHLQGAIPAHHHHLQQMPD 264
            .::|:|  ..:|.|                                |...||:.|        ..
Human   293 NLAGVAAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAA--------AA 349

  Fly   265 VAKNPLASLA------------------------ALGLAGMNPASTGGINHTANP---------- 295
            .:.||.|:.|                        |||......|:|.|....|:|
Human   350 ASANPAAAAANLLATYASEASASGSTAGGTAGTFALGSLAAATAATNGYFGAASPLAASAILGTE 414

  Fly   296 -ANRAQQQQHEMTVSNDLIGCIIGKGGTKIAEIRQISGAMIRISNCEEREGGNTDRTITISGNPD 359
             :....:...|:.|..:|:|.|:||||..:.|.::::||.|:||...|...|..:|.:||:|.|.
Human   415 KSTDGSKDVVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFVPGTRNRKVTITGTPA 479

  Fly   360 SVALAQYLINMSVELQKANLLEQAQSQQNG 389
            :...|||||...:..::.  :..|..|:.|
Human   480 ATQAAQYLITQRITYEQG--VRAANPQKVG 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mub	NP_001246875.1	PCBP_like_KH	25..86	CDD:239089	17/64 (27%)
		PCBP_like_KH	109..172	CDD:239089	22/65 (34%)
		KH-I	305..368	CDD:238053	25/62 (40%)
NOVA1	NP_002506.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Bipartite nuclear localization signal. /evidence=ECO:0000255	27..43
		PCBP_like_KH	51..117	CDD:239089	17/64 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..171		1/31 (3%)
		PCBP_like_KH	173..238	CDD:239089	22/66 (33%)
		KH-I	423..488	CDD:238053	25/64 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141640
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840