DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mub and Pcbp4

DIOPT Version :9

Sequence 1:	NP_001246875.1	Gene:	mub / 40436	FlyBaseID:	FBgn0262737	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_001178812.1	Gene:	Pcbp4 / 363133	RGDID:	1307910	Length:	403	Species:	Rattus norvegicus

Alignment Length:	476	Identity:	195/476 - (40%)
Similarity:	266/476 - (55%)	Gaps:	95/476 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TSSSAGGASIKHEDP--SVTLTIRLIMQGKEVGSIIGKKGEIVNRFREESGAKINISDGSCPERI 68
            :||.||    ..|:|  |:|||:|::|.|||||||||||||.|.|.||:|.|:|.||:|||||||
  Rat     2 SSSDAG----LEEEPELSITLTLRMLMHGKEVGSIIGKKGETVKRIREQSSARITISEGSCPERI 62

  Fly    69 VTVSGTTNAIFSAFTLITKKF-EEWCSQFNDVGKVGKTQIPIRLIVPASQCGSLIGKSGSKIKEI 132
            .|::|:|.|:|.|.::|..|. |:.|:...:.|.|.:..:.:||::|||||||||||:|:|||||
  Rat    63 TTITGSTAAVFHAVSMIAFKLDEDLCAAPANGGSVSRPPVTLRLVIPASQCGSLIGKAGTKIKEI 127

  Fly   133 RQTTGCSIQVASEMLPNSTERAVTLSGSAEQITQCIYQICLVMLESPPRGATIPYRPKPQVTGPV 197
            |:|||..:|||.::||||||||||:||..:.|..|:.|||.|:|||||:||||||.|...: |.|
  Rat   128 RETTGAQVQVAGDLLPNSTERAVTVSGVPDAIILCVRQICAVILESPPKGATIPYHPSLSL-GTV 191

  Fly   198 ILANGQAFTIQGNYAVPTQETCPVFPLALATGGLHAGISGLADPLLKGAHLQGAIPAHHHHLQQM 262
            :|:..|.|::||.|...|                                     ||....|||:
  Rat   192 LLSANQGFSVQGQYGAVT-------------------------------------PAEVTKLQQL 219

  Fly   263 PDVAKNPLASLAALGLAGMNPASTGGINHTANPANRAQQQQHEMTVSNDLIGCIIGKGGTKIAEI 327
            ...|. |.||.:.  :.|::|::              |....|..|.||||||:||:.|:||:||
  Rat   220 SGHAV-PFASPSV--VPGLDPST--------------QTSSQEFLVPNDLIGCVIGRQGSKISEI 267

  Fly   328 RQISGAMIRISNCEEREGGNTDRTITISGNPDSVALAQYLINMSVELQKANLLEQAQSQQNGGAA 392
            ||:|||.|:|.|..|..|   :|.:||:|:|.|:|||||||...:|..|:.         :||
  Rat   268 RQMSGAHIKIGNQAEGAG---ERHVTITGSPVSIALAQYLITACLETAKST---------SGG-- 318

  Fly   393 AAPGAAAAGVAAVTGAAAPTSATNGAITTVTLTSGTGVVGAGAA-------GAAGVANGANPAAN 450
             .||:|.|.:.  |..:.|.:|..        |:..|::|...|       |...|...|.|.|:
  Rat   319 -TPGSAPADLP--TPFSPPLTALP--------TAPPGLLGTPYAISLSNFIGLKPVPFLALPPAS 372

  Fly   451 GGGSNGTISATG-YASANGGQ 470
            .|...|..:.|. .|:|||.:
  Rat   373 PGPPPGLAAYTAKMAAANGSK 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mub	NP_001246875.1	PCBP_like_KH	25..86	CDD:239089	38/60 (63%)
		PCBP_like_KH	109..172	CDD:239089	41/62 (66%)
		KH-I	305..368	CDD:238053	36/62 (58%)
Pcbp4	NP_001178812.1	KH-I_PCBP4_rpt1	17..86	CDD:411945	42/68 (62%)
		KH-I_PCBP4_rpt2	101..172	CDD:411948	44/70 (63%)
		KH-I_PCBP4_rpt3	241..308	CDD:411951	38/69 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335329
Domainoid	1	1.000	97	1.000	Domainoid score	I7059
eggNOG	1	0.900	-	-		E1_KOG2190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2405
OMA	1	1.010	-	-		QHG52907
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001027
OrthoInspector	1	1.000	-	-		otm45064
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10288
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X408
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.860