DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mub and Igf2bp2

DIOPT Version :9

Sequence 1:	NP_001246875.1	Gene:	mub / 40436	FlyBaseID:	FBgn0262737	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_898850.2	Gene:	Igf2bp2 / 319765	MGIID:	1890358	Length:	592	Species:	Mus musculus

Alignment Length:	413	Identity:	86/413 - (20%)
Similarity:	165/413 - (39%)	Gaps:	102/413 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VTLTIRLIMQGKEVGSIIGKKGEIVNRFREESGAKINI---SDGSCPERIVTV----SGTTNAIF 79
            :...:|:::..:.||:||||:|..:....:::.::::|   .:....|:.||:    .||:.|..
Mouse   185 IDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEKPVTIHATPEGTSEACR 249

  Fly    80 SAFTLITKKFEEWCSQFNDVGKVGKTQIPIRLIVPASQCGSLIGKSGSKIKEIRQTTGCSIQVAS 144
            ....::.|:.:|        .|:.: ::|::::......|.||||.|..:|:|...||..|.::|
Mouse   250 MILEIMQKEADE--------TKLAE-EVPLKILAHNGFVGRLIGKEGRNLKKIEHETGTKITISS 305

  Fly   145 --EMLPNSTERAVTLSGSAEQITQCIYQICLVMLESPPRGATIPYRPKPQVTGPVILANGQAFTI 207
              ::...:.||.:|:.|:.|.......:|...:.|:              ....::..|.||..|
Mouse   306 LQDLSIYNPERTITVRGTIEACANAEIEIMKKLREA--------------FENDMLAVNQQANLI 356

  Fly   208 QGNYAVPTQETCPVFPLALATGGLHA-GISGLADPLLKGAHLQGAIPA--------H-------- 255
            .|              |.|:..|:.: |:|.|..|    |..:|..|:        |
Mouse   357 PG--------------LNLSALGIFSTGLSVLPPP----AGPRGVPPSPPYHPFATHSGYFSSLY 403

  Fly   256 -HHHLQQMPDVAKNPLASLAALGLAGMNPASTGGINHTANPANRAQQQQHEMTVSNDLIGCIIGK 319
             |||....|                          :|.:.|    :|:...:.:....:|.||||
Mouse   404 PHHHFGPFP--------------------------HHHSYP----EQETVSLFIPTQAVGAIIGK 438

  Fly   320 GGTKIAEIRQISGAMIRISNCEEREGGNTDRTITISGNPDSVALAQYLINMSVELQKANLLEQAQ 384
            .|..|.::.:.:||.|:|:..|..:  .::|.:.|:|.|::...||..|  ..:|::.|.....:
Mouse   439 KGAHIKQLARFAGASIKIAPAEGPD--VSERMVIITGPPEAQFKAQGRI--FGKLKEENFFNPKE 499

  Fly   385 SQQNGGAAAAPGAAAAGVAAVTG 407
            ..:.......|.:.|..|....|
Mouse   500 EVKLEAHIRVPSSTAGRVIGKGG 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mub	NP_001246875.1	PCBP_like_KH	25..86	CDD:239089	15/67 (22%)
		PCBP_like_KH	109..172	CDD:239089	17/64 (27%)
		KH-I	305..368	CDD:238053	18/62 (29%)
Igf2bp2	NP_898850.2	RRM1_IGF2BP2	2..78	CDD:241070
		RRM	<3..>78	CDD:223796
		RRM_SF	82..157	CDD:302621
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..182
		KH-I	189..252	CDD:238053	15/62 (24%)
		KH-I	270..335	CDD:238053	17/64 (27%)
		RhoGAP	316..>381	CDD:295372	19/96 (20%)
		PCBP_like_KH	422..486	CDD:239089	19/67 (28%)
		KH-I	504..568	CDD:238053	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831587
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840