DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mub and Igf2bp1

DIOPT Version :9

Sequence 1:	NP_001246875.1	Gene:	mub / 40436	FlyBaseID:	FBgn0262737	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_783184.1	Gene:	Igf2bp1 / 303477	RGDID:	708580	Length:	577	Species:	Rattus norvegicus

Alignment Length:	436	Identity:	91/436 - (20%)
Similarity:	170/436 - (38%)	Gaps:	101/436 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSSAGGASIKHEDPSVTLTIRLIMQGKEVGSIIGKKGEIVNRFREESGAKINI---SDGSCPERI 68
            |..|.||..|.:  .|.:.:||::..:.||:||||:|..:....:::.:||::   .:....|:.
  Rat   181 SPVAAGAPAKQQ--QVDIPLRLLVPTQYVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKA 243

  Fly    69 VTVSGTTNAIFSAFTLITKKFEEWCSQFNDVGKVGKT--QIPIRLIVPASQCGSLIGKSGSKIKE 131
            ::|..|.....||..:|.:...:       ..|..||  ::|::::...:..|.||||.|..:|:
  Rat   244 ISVHSTPEGCSSACKMILEIMHK-------EAKDTKTADEVPLKILAHNNFVGRLIGKEGRNLKK 301

  Fly   132 IRQTTGCSIQVAS--EMLPNSTERAVTLSGSAEQITQCIYQICLVMLES---------------- 178
            :.|.|...|.::|  ::...:.||.:|:.|:.|...:...:|...:.|:
  Rat   302 VEQDTETKITISSLQDLTLYNPERTITVKGAIENCCRAEQEIMKKVREAYENDVAAMSLQSHLIP 366

  Fly   179 ----------PPRGATIPYRPKPQVTGPVILANGQAFTIQGNY-AVPTQETCPVFPLALATGGLH 232
                      |...:.:| .|...|||.         ...|:: ..|.||...||..|.|.|.:
  Rat   367 GLNLAAVGLFPASSSAVP-PPPSSVTGA---------APYGSFMQAPEQEMVQVFIPAQAVGAI- 420

  Fly   233 AGISGLADPLLKGAHLQGAIPAHHHHLQQMPDVA---------KNPLASLAALGLAGMNPA---S 285
            .|..|                   .|::|:...|         :.|.:.:..:.:.|...|   :
  Rat   421 IGKKG-------------------QHIKQLSRFASASIKIAPPETPDSKVRMVVITGPPEAQFKA 466

  Fly   286 TGGI------NHTANPANRAQQQQHEMTVSNDLIGCIIGKGGTKIAEIRQISGAMIRISNCEERE 344
            .|.|      .:...|....:.:.| :.|.....|.:|||||..:.|::.::.|.:.:.. ::..
  Rat   467 QGRIYGKLKEENFFGPKEEVKLETH-IRVPASAAGRVIGKGGKTVNELQNLTAAEVVVPR-DQTP 529

  Fly   345 GGNTDRTITISGNPDSVALAQYLINMSVELQKANLLEQAQSQQNGG 390
            ..|....:.|.|:..:..:||..|.        ::|.|.:.|...|
  Rat   530 DENDQVIVKIIGHFYASQMAQRKIR--------DILAQVKQQHQKG 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mub	NP_001246875.1	PCBP_like_KH	25..86	CDD:239089	16/63 (25%)
		PCBP_like_KH	109..172	CDD:239089	16/64 (25%)
		KH-I	305..368	CDD:238053	14/62 (23%)
Igf2bp1	NP_783184.1	RRM1_IGF2BP1	1..77	CDD:241069
		RRM2_IGF2BP1	81..156	CDD:410037
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..190		4/8 (50%)
		Necessary for interaction with ELAVL4 and binding to TAU mRNA. /evidence=ECO:0000250	187..570		88/430 (20%)
		KH-I	197..272	CDD:412160	18/81 (22%)
		KH-I	273..369	CDD:412160	20/95 (21%)
		Sufficient for nuclear export. /evidence=ECO:0000250	312..323		1/10 (10%)
		KH-I	404..479	CDD:412160	17/94 (18%)
		Sufficient for nuclear export. /evidence=ECO:0000250	485..495		1/10 (10%)
		KH-I	487..562	CDD:412160	18/84 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335336
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840