DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mub and igf2bp2a

DIOPT Version :9

Sequence 1:	NP_001246875.1	Gene:	mub / 40436	FlyBaseID:	FBgn0262737	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_001108030.2	Gene:	igf2bp2a / 100136839	ZFINID:	ZDB-GENE-070912-44	Length:	607	Species:	Danio rerio

Alignment Length:	420	Identity:	101/420 - (24%)
Similarity:	175/420 - (41%)	Gaps:	85/420 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TSSSAGGASIKHEDPSVTLTIRLIMQGKEVGSIIGKKGEIVNRFREESGAKINI---SDGSCPER 67
            ||.|:.|:..|..|    ..:|:::..:.||:||||:|..:....:::.:|::|   .:....|:
Zfish   184 TSGSSLGSRQKQPD----FPLRMLVPTQFVGAIIGKEGLTIKNITKQTQSKVDIHRKENAGAAEK 244

  Fly    68 IVTVSGTTNAIFSAFTLI----------TKKFEEWCSQFNDVGKVGKTQIPIRLIVPASQCGSLI 122
            .:|:..|.....:|..:|          ||..|:               ||::::...|..|.||
Zfish   245 PITIHSTPEGCSTACHMIMDIMQKEAVDTKVTED---------------IPLKILAHNSLVGRLI 294

  Fly   123 GKSGSKIKEIRQTTGCSIQVAS--EMLPNSTERAVTLSGSAEQITQCIYQICLVMLESPPRGATI 185
            ||.|..:|:|.:.|...|.::|  ::...:.||.:.:.||.|...:...:|...:.|:
Zfish   295 GKEGRNLKKIEEDTETKITISSLQDLTIYNPERTIIVKGSIEACCRAEVEIMKKLREA------- 352

  Fly   186 PYRPKPQVTGPVILANGQAFTIQGNYAVPTQETCPVFPLALATGGLHA-GISGLADPLLKGAHLQ 249
                   ....|...|.|:..|.|              |:|:..|:.: |:|.|  |...|..
Zfish   353 -------YENDVAAINQQSNLIPG--------------LSLSALGIFSTGLSVL--PPAAGPR-- 392

  Fly   250 GAIPAHHHHLQQMPDVAKNPLASLAAL--GLAGMNPASTGGINHTANPANRAQQQQHEMTVSNDL 312
             .||       .:|....||....::.  ||.|:.|||  ||:|....|  .:|:...:.:....
Zfish   393 -GIP-------PVPPTGYNPFLGHSSQLGGLYGVPPAS--GISHQHTQA--PEQEVVYLFIPTQA 445

  Fly   313 IGCIIGKGGTKIAEIRQISGAMIRISNCEEREGGNTDRTITISGNPDSVALAQYLINMSVELQKA 377
            :|.||||.|..|.::.:.:||.|:|:..|..:  .|.|.:.|:|.|::...||..|  ..:|::.
Zfish   446 VGAIIGKKGQHIKQLARFAGASIKIAPAESPD--VTQRMVIITGPPEAQFKAQGRI--FGKLKEE 506

  Fly   378 NLLEQAQSQQNGGAAAAPGAAAAGVAAVTG 407
            |.....:..:.......|.:||..|....|
Zfish   507 NFFTAKEEVKLETHIKVPSSAAGRVIGKGG 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mub	NP_001246875.1	PCBP_like_KH	25..86	CDD:239089	15/73 (21%)
		PCBP_like_KH	109..172	CDD:239089	17/64 (27%)
		KH-I	305..368	CDD:238053	19/62 (31%)
igf2bp2a	NP_001108030.2	RRM1_IGF2BP2	1..77	CDD:241070
		RRM	<2..>77	CDD:223796
		RRM_SF	81..156	CDD:302621
		KH-I	200..263	CDD:238053	14/62 (23%)
		KH-I	281..346	CDD:238053	17/64 (27%)
		COG4020	<314..385	CDD:304975	18/98 (18%)
		PCBP_like_KH	439..500	CDD:239089	20/64 (31%)
		KH-I	518..582	CDD:238053	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574636
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840