DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh1 and ALD3

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_013892.1	Gene:	ALD3 / 855205	SGDID:	S000004779	Length:	506	Species:	Saccharomyces cerevisiae

Alignment Length:	466	Identity:	131/466 - (28%)
Similarity:	209/466 - (44%)	Gaps:	51/466 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 LASFYYADKKLIEKAIKTA-VETQPKWDRVS-------IADRLKIWEKAADLMATTYRQDLNAAT 156
            :.||..|::|.::||:|.| ......|.:.|       :::.||:.|:..|.:|..  :.|:|..
Yeast    49 ITSFQAANEKDVDKAVKAARAAFDNVWSKTSSEQRGIYLSNLLKLIEEEQDTLAAL--ETLDAGK 111

  Fly   157 MLGQSKTAIQAEIDSAAELIDFIRMNAYFLKEVTKYQPISENIKVTKNSLRY--RGIDGFIAAVS 219
            ..         ..::..:|...|.:..|:...|.|:. :.|.|.:|.|...|  :...|.:|.:.
Yeast   112 PF---------HSNAKQDLAQIIELTRYYAGAVDKFN-MGETIPLTFNKFAYTLKVPFGVVAQIV 166

  Fly   220 PFNFTAIGGNLSYTPAL-MGNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDT 283
            |:|:...........|| .||.|:.||::...||......::::||.|.||||.:|..|.|.|..
Yeast   167 PWNYPLAMACRKMQGALAAGNTVIIKPAENTSLSLLYFATLIKKAGFPPGVVNVIPGYGSVVGKA 231

  Fly   284 ITASPHLAGINFTGSVPTFNRLWKQVGNNI---DNYVNFPRLTGECGGKNFHFIHASADVESVVT 345
            :.....:..|:||||.        :||.::   ....|...:|.|||||:...:...||::..:.
Yeast   232 LGTHMDIDKISFTGST--------KVGGSVLEASGQSNLKDITLECGGKSPALVFEDADLDKAIE 288

  Fly   346 STIRSAFEYCGQKCSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQ------DFSSFTSAVIDD 404
            ......|...||.|:|.||:||..|::.:..|... |.|| |..||.      |.......||..
Yeast   289 WVANGIFFNSGQICTANSRVYVQSSIYDKFVEKFK-ETAK-KEWDVAGKFDPFDEKCIVGPVISS 351

  Fly   405 KAFKRITGYIEHAKKSPNLEILAGGTY--SDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYV 467
            ..:.||..|||..||...|::.....:  ..:||||:.|||........:::.:||||||:.:..
Yeast   352 TQYDRIKSYIERGKKEEKLDMFQTSEFPIGGAKGYFIPPTIFTDVPETSKLLRDEIFGPVVVVSK 416

  Fly   468 YKESDLLETMKLVHTSTKFALTGAVFGQDEDFVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGG 532
            :...|  :.:||.: .|.:.|..|||.:|........::.|  ||..:||  .|.....:.||||
Yeast   417 FTNYD--DALKLAN-DTCYGLASAVFTKDVKKAHMFARDIK--AGTVWIN--QTNQEEAKVPFGG 474

  Fly   533 GRMSGTNDKAG 543
            .:|||...::|
Yeast   475 FKMSGIGRESG 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	131/466 (28%)
ALD3	NP_013892.1	ALDH-SF	14..502	CDD:416387	131/466 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810