Protein Alignment P5CDh1 and ALDH5A1

DIOPT Version :9

• Sequence 1: NP_001189159.1
• Gene: P5CDh1 / 40434
• FlyBaseID: FBgn0037138
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_733936.1
• Gene: ALDH5A1 / 7915
• HGNCID: 408
• Length: 548
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 128/572 - (22%)
• Similarity: 230/572 - (40%)
• Gaps: 82/572 - (14%)

  Fly    19 LLKSSTRCLGSVIPDLKLKDFPIANEPILGYLKDSKERKALEQALKGTASSCEDIPIVIGGKEYK 83
            |.....|.|||..|..:|:.......|..|......:.:.....|.|.:::.......:||: :.
Human     7 LRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGR-WL 70

  Fly    84 TPEVRYQVMPHDHQHKLASFYYADKKLIE--KAIKTAVETQPKWDRVSIADRLKIWEKAADLMAT 146
            .....:.|  .|.....|....||..:.|  .|::.|.|...:|..||..:|..:..|..:||..
Human    71 PAAATFPV--QDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQ 133

  Fly   147 TYRQDLNAATMLGQSKTAIQAEIDSAAELIDFIRMNAYFLKEVTK-----YQPISENIKVTKNSL 206
            . :.|| |..:..:|...::   ::..|::    .:|:||:..::     |..|.......:.:|
Human   134 N-KDDL-ARIITAESGKPLK---EAHGEIL----YSAFFLEWFSEEARRVYGDIIHTPAKDRRAL 189

  Fly   207 RYRGIDGFIAAVSPFNFTA------IGGNLSYTPALMGNGVLWKPSDTAMLSNWIIFKIMR---- 261
            ..:...|..|.::|:||.:      :|..|:     .|..|:.||::....|...:.::.:
Human   190 VLKQPIGVAAVITPWNFPSAMITRKVGAALA-----AGCTVVVKPAEDTPFSALALAEVNQGFLL 249

  Fly   262 ---------EAGVPDGVVNFVPA---DGPVFGDTITASPHLAGINFTGSVPTFNRLWKQVGNNID 314
                     :||:|.||.|.:|.   :....|:.|...|.::.|:||||..|...|.....|::
Human   250 DLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV- 313

  Fly   315 NYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQKCSACSRMYVPESLWPQIKEGL 379
                 .|::.|.||.....:..||:|:..|...:.|.|...||.| .||..::       ::.|:
Human   314 -----KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTC-VCSNQFL-------VQRGI 365

  Fly   380 -------VCEAAK--LKIGDVQDFSSFTSAVIDDKAFKRITGYIEHAKKSPNLEILAGGTYSDSK 435
                   ..||.|  |::|:..:..:....:|::||.:::...:..| .|....::.||......
Human   366 HDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDA-VSKGATVVTGGKRHQLG 429

  Fly   436 GYFVNPTIVLSKDPKDRIMT-EEIFGPVLSIYVYKESDLLETMKLVHTSTKFALTGAVFGQDEDF 499
            ..|..||: |....:|.:.| ||.|||:..:..:   |..|....:..:....|.|..:.||...
Human   430 KNFFEPTL-LCNVTQDMLCTHEETFGPLAPVIKF---DTEEEAIAIANAADVGLAGYFYSQDPAQ 490

  Fly   500 VKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSG---TNDKAGGPHYI 548
            :....::.::  |...:|:....||  :.||||.:.||   ...|.|...|:
Human   491 IWRVAEQLEV--GMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYGIDEYL 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	121/550 (22%)
ALDH5A1	NP_733936.1	SSADH	78..541	CDD:188167	115/500 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900