DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P5CDh1 and aldh1a3

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001038210.1	Gene:	aldh1a3 / 751785	ZFINID:	ZDB-GENE-061128-2	Length:	513	Species:	Danio rerio

Alignment Length:	502	Identity:	150/502 - (29%)
Similarity:	236/502 - (47%)	Gaps:	67/502 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 GKEYKTPEVRYQVMPHDHQHKLASFYYADKKLIEKAIKTAVETQPK---WDRVSIADRLKIWEKA 140
            ||::.|......|       |:.....|||..:::|:|.|.....:   |.|:..:.|.::..:.
Zfish    46 GKQFPTINPATGV-------KICDIEEADKADVDEAVKAAKAAGQRGSVWRRMDASSRGRLLNRL 103

  Fly   141 ADLMATTYRQDLNAATMLGQSKT-------AIQAEIDSAAELIDFIRMNAYFLKEV-TKYQPISE 197
            |||:.   |:....||:  :||.       |...::|.:   |..:|..|.:..:: .|..|:.|
Zfish   104 ADLLE---RERAVLATL--ESKDTGKPFLHAFFVDLDGS---IKTLRYYAGWTDKIHGKTMPVDE 160

  Fly   198 N-IKVTKNSLRYRGIDGFIAAVSPFNFTAIGGNLSYTPAL-MGNGVLWKPSDTAMLSNWIIFKIM 260
            | :..||:.     ..|...|:.|:||..:.......||| .||.|:.||::...|:...:..::
Zfish   161 NFVCFTKHE-----PIGVCGAIIPWNFPLLMLMWKIAPALACGNTVVLKPAEQTPLTALHVAALI 220

  Fly   261 REAGVPDGVVNFVPADGPVFGDTITASPHLAGINFTGSVPTFNRLWKQVGNNIDNYV---NFPRL 322
            :|||.|.||||.||..||..|..|....::..:.||||.        :||..:....   |..|:
Zfish   221 KEAGFPPGVVNVVPGFGPTAGAAIAGHMNIDKLAFTGST--------EVGQLVKAAAASSNLKRV 277

  Fly   323 TGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQKCSACSRMYVPESLWPQIKEGLVCEAAKLK 387
            |.|.||||...:.|.:|::..|..|.:.||...||.|:|.||:||.|.::.:.....|..|..:.
Zfish   278 TLELGGKNPCIVFADSDLQLAVEETQKGAFFNQGQACTAASRVYVQEPVYEEFVRLSVERAKNIV 342

  Fly   388 IGDVQDFSSFTSAVIDDKAFKRITGYIEHAKK-SPNLEILAGGTYSDSKGYFVNPTIVLSKDPKD 451
            |||..:..:.....||...|::|...::..|| ...||.  ||...:.:|.|::|||.  .|.||
Zfish   343 IGDPMEPRTSHGPQIDQHQFEKILALVDSGKKEGAKLEF--GGCAVEDRGLFIHPTIF--SDVKD 403

  Fly   452 --RIMTEEIFGPVLSIYVYK-ESDLLETMKLVHTSTKFALTGAVFGQDED---FVKCALQEFKMA 510
              ||..|||||||..|..:: :.|:::..    .|::|.||.|||.:|..   .|..||:
Zfish   404 HMRIAKEEIFGPVQCIMKFECQQDVIDRA----NSSQFGLTAAVFTRDVQRAMSVSAALE----- 459

  Fly   511 AGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAGGPHYILRWTSPQSI 557
            ||..::|  ...::..|.||||.:||| |.:..|.:.:..:|..::|
Zfish   460 AGTVWVN--CYNALHAQTPFGGYKMSG-NGRELGEYALAEYTEVKAI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	150/502 (30%)
aldh1a3	NP_001038210.1	ALDH_F1AB_F2_RALDH1	28..506	CDD:143459	150/502 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810