DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh1 and aldh16a1

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001039089.1	Gene:	aldh16a1 / 733905	XenbaseID:	XB-GENE-5726619	Length:	829	Species:	Xenopus tropicalis

Alignment Length:	506	Identity:	125/506 - (24%)
Similarity:	217/506 - (42%)	Gaps:	54/506 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 IGGKEYKTPEVR--YQVMPHDHQHKLASFYYADKKLIEKAIKTAVETQPKWDRVSIADRLKIWEK 139
            |.||..| ||.|  |..........|||....:::.:|.|:|.|.:....|.::....|.:....
Frog    46 IDGKWLK-PEGRNTYTTKNPATGEALASTVQGEEEDVETAVKAARKAFESWSKLPCHVRARYLYS 109

  Fly   140 AADLMATTYRQDLNAATMLGQSKTAIQAEIDSAAELIDFIRMNAYFLK----EVTKYQPISENIK 200
            .|..: ..:::.|:....:...|...:|.......::.....:|.:.:    |:..::|:
Frog   110 IARTV-QKHQRLLSVIESMDNGKPIREARDCDVPLVVRHFYHHAGWAQLRDTEMNGWKPL----- 168

  Fly   201 VTKNSLRYRGIDGFIAAVSPFNFTAIGGNLSYTPAL-MGNGVLWKPSDTAMLSNWIIFKIMREAG 264
                        |.|||:.|:||..:.......||| |||.|:.||:....|:..::.:|..|||
Frog   169 ------------GVIAAIVPWNFPLMLLTWKICPALAMGNTVVLKPATYTRLTALLLAEICAEAG 221

  Fly   265 VPDGVVNFVPADGPVFGDTITASPHLAGINFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECGGK 329
            :|.||.|.|..:| .||..:...|.:..:.||||......|.|....      ...:|:.|.|||
Frog   222 LPPGVFNVVTGNG-AFGGKLADHPDVDKVAFTGSTEVGRTLRKATAG------TGKKLSLELGGK 279

  Fly   330 NFHFIHASADVESVVTSTIRSAFEYCGQKCSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQDF 394
            :...:..::|::|.|...:.:.:...||.|||.||:.:.||:...:...|....:.|::||..|.
Frog   280 SPFIVFDTSDLDSAVEGIVDAIWFNQGQVCSAGSRLLMQESIAEDLIRRLKQRMSHLRLGDSLDK 344

  Fly   395 SSFTSAVIDDKAFKRITGYIEHAKKSPNLEILAGGTYSDSKGYFVNPTIVLSKDPKDRIMTEEIF 459
            :....|::|:...|.|..::|.| ::...::.........||.|..||::...:...|.:.||||
Frog   345 AIDVGALVDETQKKTIEEFVEEA-QAEGADVFQSPGPIPKKGLFYPPTLITGVNTTSRCVREEIF 408

  Fly   460 GPVLSIYVYKESDLLETMKLVHTSTKFALTGAVFGQDEDFVKCALQ-EFKMAAGNFYIN-----D 518
            ||||....::.:.  |.:.| ..:|.:.|..:|:.::   :..||: ...:.||..::|     |
Frog   409 GPVLVAMTFRTAK--EAIAL-GNNTPYGLAASVWTEN---LPLALEVAISIKAGTVWVNGHNMFD 467

  Fly   519 KSTGSVVGQQPFGGGRMSGTNDKAGGPHYILRWTSPQSIKETFVPLRDVNY 569
            .:.|       |||.:.||.. :.||...:..:..|...........:|||
Frog   468 AAAG-------FGGYKESGFG-RDGGKEGLYEYVRPSWESRPQPSPGEVNY 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	122/498 (24%)
aldh16a1	NP_001039089.1	ALDH_F16	21..500	CDD:143429	122/494 (25%)
aldh16a1	NP_001039089.1	ALDH-SF	572..>788	CDD:299846
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910