Protein Alignment P5CDh1 and ALDH8A1

DIOPT Version :9

• Sequence 1: NP_001189159.1
• Gene: P5CDh1 / 40434
• FlyBaseID: FBgn0037138
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_072090.1
• Gene: ALDH8A1 / 64577
• HGNCID: 15471
• Length: 487
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 132/514 - (25%)
• Similarity: 218/514 - (42%)
• Gaps: 74/514 - (14%)

  Fly    59 LEQALKGTASSCEDIPIVIGGKEYKTPEVRYQVMPHDHQHKLASFYYADKKLIEKAIKTAVETQP 123
            ||..:.|....|..   .|...:..|.|| |..:|:           :.|..||.|:|.|.|..|
Human    10 LENFIDGKFLPCSS---YIDSYDPSTGEV-YCRVPN-----------SGKDEIEAAVKAAREAFP 59

  Fly   124 KWDRVSIADRLKIWEKAADLMATTYRQDLNAATMLGQSKT-AIQAEID---SAAELIDFIRMNAY 184
            .|...|..:|.::..:.|||:..:. ::...|....|.|| |:...:|   |......|...:.:
Human    60 SWSSRSPQERSRVLNQVADLLEQSL-EEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLH 123

  Fly   185 FLKEVTKYQPISENIKVTKNSLRY--RGIDGFIAAVSPFNFTAIGGNLSYTPAL-MGNGVLWKPS 246
            ...|.|:...:        ..:.|  |...|....:||:|...........||: .||.|:.|||
Human   124 HTSECTQMDHL--------GCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS 180

  Fly   247 DTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAGINFTGSVPTFNRLWKQVGN 311
            :...::.|::.|::.:||||.||||.|...||..|:.:.:.|.:..|:||||.||..|:
Human   181 ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERI------ 239

  Fly   312 NIDNYVNFP---RLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQKCSACSRMYVPESLWP 373
               ..::.|   :|:.|.||||...|...|:::..:.:|:||:|...|:.|...||::|.:|::.
Human   240 ---TQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYS 301

  Fly   374 QIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHAKKSPNLEILAGGTY------- 431
            :..:..|....|.|:|...|......|:|.....:::..|::.|        ||.|..
Human   302 EFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRA--------LAEGAQIWCGEGV 358

  Fly   432 -------SDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVY-KESDLLETMKLVHTSTKFAL 488
                   .:..|||:.||::.....:...|||||||||..:..: .|.:::|..    .:.|:.|
Human   359 DKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERA----NNVKYGL 419

  Fly   489 TGAVFGQDEDFVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAGGPHY 547
            ...|:..:...|....:  |:.:|..:.|......:  ..||||.:.||...:.....|
Human   420 AATVWSSNVGRVHRVAK--KLQSGLVWTNCWLIREL--NLPFGGMKSSGIGREGAKDSY 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	132/514 (26%)
ALDH8A1	NP_072090.1	ALDH_F8_HMSADH	27..485	CDD:143412	127/494 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810