DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P5CDh1 and Aldh1a3

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_444310.3	Gene:	Aldh1a3 / 56847	MGIID:	1861722	Length:	512	Species:	Mus musculus

Alignment Length:	482	Identity:	144/482 - (29%)
Similarity:	221/482 - (45%)	Gaps:	41/482 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 KLASFYYADKKLIEKAI---KTAVETQPKWDRVSIADRLKIWEKAADLMATTYRQDLNAATMLGQ 160
            |:......||..::||:   :.|.:....|.|:....|.::..:.|||:... |..|.....:..
Mouse    59 KICEVEEGDKPDVDKAVEAAQAAFQRGSPWRRLDALSRGQLLHQLADLVERD-RAILATLETMDT 122

  Fly   161 SKTAIQAEIDSAAELIDFIRMNAYFLKEVTKYQ----PISENIKVTKNSLRYRGIDGFIAAVSPF 221
            .|..:.|..   .:|...|:...||.....|.|    |..:|:..   ..|:..| |...|::|:
Mouse   123 GKPFLHAFF---VDLEGCIKTFRYFAGWADKIQGRTIPTDDNVVC---FTRHEPI-GVCGAITPW 180

  Fly   222 NFTAIGGNLSYTPAL-MGNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTIT 285
            ||..:.......||| .||.|:.||::...|:...:..:::|.|.|.||||.||..||..|..|:
Mouse   181 NFPLLMLAWKLAPALCCGNTVVLKPAEQTPLTALYLASLIKEVGFPPGVVNIVPGFGPTVGAAIS 245

  Fly   286 ASPHLAGINFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRS 350
            :.|.:..|.||||... .:|.::..:.    .|..|:|.|.||||...:.|.||::..|....:.
Mouse   246 SHPQINKIAFTGSTEV-GKLVREAASR----SNLKRVTLELGGKNPCIVCADADLDLAVECAHQG 305

  Fly   351 AFEYCGQKCSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIE 415
            .|...||.|:|.||::|.|.::.:.....|..|.|..:||..|..:.....||.|.|.:|...||
Mouse   306 VFFNQGQCCTAASRVFVEEQVYGEFVRRSVEFAKKRPVGDPFDAKTEQGPQIDQKQFDKILELIE 370

  Fly   416 HAKKSPNLEILAGGTYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDLLETMKLV 480
            ..||. ..::..||:..:.:|.|:.||:........||..|||||||..|..:|  :|.|.:|..
Mouse   371 SGKKE-GAKLECGGSAMEDRGLFIKPTVFSDVTDNMRIAKEEIFGPVQPILKFK--NLEEVIKRA 432

  Fly   481 HTSTKFALTGAVFGQDEDFVKCALQEFKMAA----GNFYINDKSTGSVVGQQPFGGGRMSGTNDK 541
            : ||.:.||.|||.::.|      :..|:||    |..:||  ...:...|.||||.:||| |.:
Mouse   433 N-STDYGLTAAVFTKNLD------KALKLAAALESGTVWIN--CYNAFYAQAPFGGFKMSG-NGR 487

  Fly   542 AGGPHYILRWTSPQSIKETFVPLRDVN 568
            ..|.:.:..:|   .:|...:.|.:.|
Mouse   488 ELGEYALAEYT---EVKTVTIKLEEKN 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	142/475 (30%)
Aldh1a3	NP_444310.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
Aldh1a3	NP_444310.3	ALDH_F1AB_F2_RALDH1	26..506	CDD:143459	142/475 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810