DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh1 and ALDH7A1

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001173.2	Gene:	ALDH7A1 / 501	HGNCID:	877	Length:	539	Species:	Homo sapiens

Alignment Length:	525	Identity:	119/525 - (22%)
Similarity:	213/525 - (40%)	Gaps:	72/525 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 IANEPILGYLKDSKERKALEQALKGTASSCEDIPIVIGGKEYKTPEVRYQVMPHDHQHKLASFYY 105
            :.|:|...:||:...|:..|....|:          .||:    .||.....|.::: .:|....
Human    33 LINQPQYAWLKELGLREENEGVYNGS----------WGGR----GEVITTYCPANNE-PIARVRQ 82

  Fly   106 ADKKLIEKAIKTAVETQPKWDRVSIADRLKIWEKAADLMATTYRQDLNAATMLGQSKTAIQ--AE 168
            |.....|:.:|.|.|....|..:....|.:|..:..|.:.... |.|.:...|...|..::  .|
Human    83 ASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKI-QVLGSLVSLEMGKILVEGVGE 146

  Fly   169 IDSAAELIDFI----RM----------NAYFLKEVTKYQPISENIKVTKNSLRYRGIDGFIAAVS 219
            :....::.|:.    ||          :.:.|  :.::.|:                 |.:..::
Human   147 VQEYVDICDYAVGLSRMIGGPILPSERSGHAL--IEQWNPV-----------------GLVGIIT 192

  Fly   220 PFNF-TAIGGNLSYTPALMGNGVLWKPSDTAMLSN----WIIFKIMREAGVPDGVVNFVPADGPV 279
            .||| .|:.|..:....:.||..|||.:.|..|.:    .||.|::.:..:| |.:..:...|..
Human   193 AFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLP-GAICSLTCGGAD 256

  Fly   280 FGDTITASPHLAGINFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVV 344
            .|..:.....:..::||||    .::.||||..:..  .|.|...|.||.|.......||:..||
Human   257 IGTAMAKDERVNLLSFTGS----TQVGKQVGLMVQE--RFGRSLLELGGNNAIIAFEDADLSLVV 315

  Fly   345 TSTIRSAFEYCGQKCSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKR 409
            .|.:.:|....||:|:...|:::.||:..::...|....|::::|:..|.:.....:...:|...
Human   316 PSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSM 380

  Fly   410 ITGYIEHAKKSPNLEILAGGTYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDLL 474
            ..|.:|.|||... .::.||...|..|.:|.||||........|...|.|.|:|.::.:|..
Human   381 FLGAVEEAKKEGG-TVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNE--- 441

  Fly   475 ETMKLVHTSTKFALTGAVFGQDEDFVKCALQEFKMAAGNFYINDKSTGSVV-----GQQPFGGGR 534
            |.:...:...|..|:.::|.:|...:...|.......|...:|..::|:.:     |::..||||
Human   442 EEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGR 506

  Fly   535 MSGTN 539
            .||::
Human   507 ESGSD 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	119/525 (23%)
ALDH7A1	NP_001173.2	ALDH_F7_AASADH	53..527	CDD:143448	113/505 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810