DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P5CDh1 and aldh3a2b

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001315147.1	Gene:	aldh3a2b / 447920	ZFINID:	ZDB-GENE-040912-103	Length:	490	Species:	Danio rerio

Alignment Length:	524	Identity:	112/524 - (21%)
Similarity:	197/524 - (37%)	Gaps:	149/524 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 SKERKALEQALK----GTASSCEDIPIVIGGKEYKTPEVRYQVMPHDHQHKLASFYYADKKLIEK 113
            |:|:||:|:|.|    |.:.|.          ||:..:::          .|..|....:|.|.:
Zfish     2 SREQKAVERARKAFFTGRSKSL----------EYRISQLK----------NLQRFMQERQKEIAE 46

  Fly   114 AIKTAVETQPKWDRVSIADRLKIWEKAADLMATTYRQDLNAATMLGQSKTAIQAEIDSAAELIDF 178
            |:|               ..||..|....|..|           ||     :::||:.|.:.
Zfish    47 ALK---------------KDLKRSEFGTSLYET-----------LG-----VESEINLALKK--- 77

  Fly   179 IRMNAYFLKEVTKYQPISENIKVTKNSLRYRGID-GFIAAVSPFNF---TAIGGNLSYTPALMGN 239
                   |||....:|:::::....:.:..:... |.:..:..:|:   ..:|..:....|  ||
Zfish    78 -------LKEWAAPRPVNKSLMTISDQVYIQPEPLGVVLIIGAWNYPWAVTVGPLVGAIAA--GN 133

  Fly   240 GVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAGINFTGSVPTFNR 304
            ..:.|||:.:..::    |:|.|         |:|         :.....|..: .||.|.....
Zfish   134 AAVIKPSEVSAHTS----KVMEE---------FLP---------LYLDKELYPV-VTGGVKETQE 175

  Fly   305 LWKQ-------VGNNIDNYV-------NFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYC 355
            |.||       .||.:...:       :....|.|.|||:..:|....|:...........:..|
Zfish   176 LLKQRFDHIFYTGNGMVGKIIMEAAAKHLTPTTLELGGKSPCYIDKDCDLTIACRRIAWGKYSNC 240

  Fly   356 GQKCSACSRMYVPESLW--PQIKEGLVCEAAKLKIGDVQDFSSFT---------SAVIDDKAFKR 409
            ||.|.|      |:.:.  |.|::.::.|..|    ::::|  :|         ..:|:.:.|||
Zfish   241 GQTCIA------PDYILCDPSIQDRVIEEIKK----NIKEF--YTENPQKCPDYGRIINQRHFKR 293

  Fly   410 ITGYIEHAKKSPNLEILAGGTYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDLL 474
            :...:|.:      .|...|.:::::.| :.||::....|..::|.||||||:|.|......|
Zfish   294 LMSLMEGS------SIAVSGEHNEAECY-IAPTVLRDVKPDAKVMQEEIFGPLLPIVTVNSVD-- 349

  Fly   475 ETMKLVHTSTKFALTGAVFGQDEDFVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGG------G 533
            |.:|.::...| .|...:|..|:..:...:.|  .::|....||......|...||||      |
Zfish   350 EAIKFINQRDK-PLALYIFSSDKKLIDRMIAE--TSSGGLMANDCLMHFSVSSLPFGGVGDSGMG 411

  Fly   534 RMSG 537
            |..|
Zfish   412 RYHG 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	112/524 (21%)
aldh3a2b	NP_001315147.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900