DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh1 and CG6661

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_648686.3	Gene:	CG6661 / 39556	FlyBaseID:	FBgn0036403	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	584	Identity:	219/584 - (37%)
Similarity:	329/584 - (56%)	Gaps:	42/584 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SSRCSSL-QQSLLKSSTRC---------------LGSVIPDLKLKDFPIANEPILGYLKDSKERK 57
            |.||..| ..:::|..|:.               ...|.||.:    |....|.:    ...:|.
  Fly    13 SFRCRRLGGMAIIKGETKISVDKQKAVQPEQDEDQQEVEPDSQ----PAEENPSI----HRNQRV 69

  Fly    58 ALEQALKGTASSCEDIPIVIGGKEYKTPEVRYQVMPHDHQHKLASFYYADKKLIEKAIKTAVETQ 122
            .:..|::.......::|.:||.....|.:.:....||..|..||..|||::|.||.|||:|:..|
  Fly    70 LVNHAIQEIQHRPLEVPTIIGDDTVYTMDTQRVCCPHHLQTNLAHVYYANRKQIEAAIKSALSAQ 134

  Fly   123 PKWDRVSIADRLKIWEKAADLMATTYRQD---LNAATMLGQSKTAIQAEIDSAAELIDFIRMNAY 184
            ..|..|.||.||.||.:|    ||...:|   |....|:..||||..|..| ...|:..:|.||.
  Fly   135 GTWSLVPIAQRLAIWRRA----ATIIEEDELRLRVFLMMTLSKTADDATRD-IRRLLTSLRANAD 194

  Fly   185 FLKEVTKYQ-PISENIKVTKNSLRYRGIDGFIAAVSPFNFTAIGGNLSYTPALMGNGVLWKPSDT 248
            :|:.:::.: .|..::.|.. |...|.:|||:||::||...|:..:|:..||||||.|||.||..
  Fly   195 YLEHLSELRFEIQGDMNVFP-SFHLRPMDGFVAALAPFESVALSSSLALCPALMGNTVLWNPSLE 258

  Fly   249 AMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAGINFTGSVPTFNRLWKQVGNNI 313
            ....:::||:..:|||:|.||:|||||:..:|.||||.:.|.||:|...|...:..:.|.|.:.:
  Fly   259 VAPVSYLIFRAFQEAGLPSGVINFVPANERLFLDTITDAVHFAGLNTQASAAFYRHVHKLVSDRM 323

  Fly   314 DNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQKCSACSRMYVPESLWPQIKEG 378
            :.|:.||||..||.|:||||:||||.|||||::|:::||.:.||..::.||||||.|:||:::|.
  Fly   324 ERYICFPRLVAECPGQNFHFVHASAKVESVVSATVQAAFGFAGQYANSLSRMYVPSSMWPRLREE 388

  Fly   379 LVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHAKKSPNLEILAGGTYSDSKGYFVNPTI 443
            ||....:|.|||..:..:...|::....|:|:...::..|   |:|.|.||:..||.|.||:|||
  Fly   389 LVEATEQLTIGDPIESETDIGAMVHINDFRRMQKLLQRTK---NMEQLCGGSCDDSTGRFVDPTI 450

  Fly   444 VLSKDPKDRIMTEEIFGPVLSIYVYKESDLLETMKLVHTSTKFALTGAVF-GQDEDFVKCALQEF 507
            |...||.|.::.|...||.|.::||.:....|.:||....:::||:|::| .|||..:.| |.:.
  Fly   451 VRVSDPLDPLLCEPCCGPFLPVFVYSDDSFSEALKLAANQSRYALSGSIFASQDEVILHC-LNQL 514

  Fly   508 KMAAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAGGPHYILRWTSPQSIKETF---VPLRDVN 568
            :|:|.|.|:|::.|||..|..||||.|:||||||:|..::::||:||..|:||.   .|:|..|
  Fly   515 RMSASNLYVNERCTGSTYGLTPFGGNRLSGTNDKSGSAYFLMRWSSPLLIEETVDGPPPMRGSN 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	206/529 (39%)
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:299846	203/508 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469347
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S619
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D293592at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42862
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.800