DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P5CDh1 and aldh4a1

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_957452.1	Gene:	aldh4a1 / 394133	ZFINID:	ZDB-GENE-040426-1179	Length:	556	Species:	Danio rerio

Alignment Length:	533	Identity:	315/533 - (59%)
Similarity:	415/533 - (77%)	Gaps:	3/533 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 IANEPILGYLKDSKERKALEQALKGTASSCEDIPIVIGGKEYKTPEVRYQVMPHDHQHKLASFYY 105
            :.|||:|.:.:.||||..||:||:......|:||.|||.:|..|.::|:|:.|.:|.|::|.|.|
Zfish    25 VKNEPVLEFKEGSKERAELEEALRNLKGKTEEIPCVIGNEEVWTKDIRFQLSPFNHSHQVAKFCY 89

  Fly   106 ADKKLIEKAIKTAVETQPKWDRVSIADRLKIWEKAADLMATTYRQDLNAATMLGQSKTAIQAEID 170
            |||.|:.|||:.:|..:.:||...::||.:|:.||||:::...|.::.|.||:||.||.:|||||
Zfish    90 ADKDLLNKAIEASVAARREWDLKPVSDRAQIFFKAADIISGPKRAEVLAKTMIGQGKTVVQAEID 154

  Fly   171 SAAELIDFIRMNAYFLKEVTKYQPISENIKVTKNSLRYRGIDGFIAAVSPFNFTAIGGNLSYTPA 235
            :|.|||||.|.||....|:...||:..:  .:.|::.|||::||:|||:|||||||||||:.|||
Zfish   155 AAPELIDFFRFNAKHAIELEDQQPLDSD--GSTNTMLYRGLEGFVAAVAPFNFTAIGGNLAGTPA 217

  Fly   236 LMGNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAGINFTGSVP 300
            ||||.||||||||||.:::.::||:||:|:|..::.||||||||||||:|:|.||||||||||||
Zfish   218 LMGNVVLWKPSDTAMSASYAVYKILRESGLPPNIIQFVPADGPVFGDTVTSSEHLAGINFTGSVP 282

  Fly   301 TFNRLWKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQKCSACSRM 365
            ||.||||||..|:|.|.||||:.||||||||||:|.||||.||||.||||||||.||||||||||
Zfish   283 TFKRLWKQVAQNLDIYKNFPRVAGECGGKNFHFVHKSADVRSVVTGTIRSAFEYGGQKCSACSRM 347

  Fly   366 YVPESLWPQIKEGLVCEAAKLKIGD-VQDFSSFTSAVIDDKAFKRITGYIEHAKKSPNLEILAGG 429
            |||:||||||::||:....::|:|| |:|||:|.|||||||:|.||.|::|||:.||:|:|:|||
Zfish   348 YVPDSLWPQIRQGLLDVYKQIKVGDPVEDFSTFFSAVIDDKSFSRIKGWLEHARSSPHLKIIAGG 412

  Fly   430 TYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDLLETMKLVHTSTKFALTGAVFG 494
            ...|.|||||.|||:.:.||:::||.||||||||::|||.|:|..:.:.|:..::.:|||||:|.
Zfish   413 NCDDKKGYFVEPTIIETTDPQEKIMNEEIFGPVLTVYVYPENDYKKVLHLIDNTSPYALTGAIFP 477

  Fly   495 QDEDFVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAGGPHYILRWTSPQSIKE 559
            ||:..::.|.:..:.||||:|||||||||:|.||||||.|.||||||.|||||:|||||||.:|:
Zfish   478 QDKSVIEEAGKALRNAAGNYYINDKSTGSIVAQQPFGGARASGTNDKPGGPHYVLRWTSPQVVKQ 542

  Fly   560 TFVPLRDVNYPYM 572
            |.|||.:..||||
Zfish   543 THVPLTEWKYPYM 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	308/522 (59%)
aldh4a1	NP_957452.1	ALDH_F4-17_P5CDH	25..546	CDD:143441	308/522 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595399
Domainoid	1	1.000	602	1.000	Domainoid score	I188
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6081
Inparanoid	1	1.050	667	1.000	Inparanoid score	I726
OMA	1	1.010	-	-		QHG63568
OrthoDB	1	1.010	-	-		D293592at33208
OrthoFinder	1	1.000	-	-		FOG0004722
OrthoInspector	1	1.000	-	-		oto40391
orthoMCL	1	0.900	-	-		OOG6_102275
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1040
SonicParanoid	1	1.000	-	-		X3320
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.840