DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh1 and aldh2.1

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_956784.1	Gene:	aldh2.1 / 393462	ZFINID:	ZDB-GENE-040426-1262	Length:	516	Species:	Danio rerio

Alignment Length:	562	Identity:	152/562 - (27%)
Similarity:	242/562 - (43%)	Gaps:	87/562 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRMMRSSS----SRCSSLQQSLLKSSTRCLGSVIPDLKLKDFPIANEPILGYLKDSKERKALEQ 61
            |||.:.|.:    .|.||.|.|.:.:.     :|.||:......|.||     ..|:..:|....
Zfish     1 MLRTVFSRTFPQVFRISSCQHSTIPAP-----NVQPDVHYNKIFINNE-----WHDAVSKKTFPT 55

  Fly    62 ALKGTASSCEDIPIVIGGKEYKTPEVRYQVMPHDHQHKLASFYYADKKLIEKAIKTAVET----Q 122
            ....||                      :|:.|..:        .||..::||:|.|.:.    .
Zfish    56 INPATA----------------------EVICHVAE--------GDKADVDKAVKAARDAFKLGS 90

  Fly   123 PKWDRVSIADRLKIWEKAADLMATTYRQDLNAATMLGQSKTAIQAEIDSAAELIDF---IRMNAY 184
            | |.|:..:.|..:..:.||.:    .:|   |..|.:.:|....:..:.:..:|.   ::...|
Zfish    91 P-WRRMDASQRGLLLNRLADCI----ERD---AAYLAELETLDNGKPYTLSFCVDLPMVVKCLRY 147

  Fly   185 FLKEVTKYQPISENIKVTKNSLRYRGID--GFIAAVSPFNFTAIGGNLSYTPAL-MGNGVLWKPS 246
            :.....|::  .:.|.:..|...|...:  |....:.|:||..:...|...||| .||.|:.|.:
Zfish   148 YAGWADKWE--GKTIPIDGNYFCYTRHEPIGVCGQIIPWNFPLLMQALKLGPALATGNTVVMKVA 210

  Fly   247 DTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAGINFTGSVPTFNRLWKQVGN 311
            :...|:...|..:::|.|.|.||||.||..||..|..|.:...:..:.||||.        .||:
Zfish   211 EQTPLTALYIASLIKEVGFPAGVVNIVPGFGPTAGAAIASHMDVDKVAFTGST--------DVGH 267

  Fly   312 NI---DNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQKCSACSRMYVPESLWP 373
            .|   .:..|...::.|.|||:.:.|.:.|::|..|.....:.|...||.|.|.:|.:|.||::.
Zfish   268 LIQQASSASNLKNVSLELGGKSPNIILSDANMEEAVEQAHSALFFNQGQCCCAGTRTFVQESIYD 332

  Fly   374 QIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHAKKSPNLEILAGGTYSDSKGYF 438
            :..|..|..|....:||..|.::.....:|:..||::.|||...|:. ..:::.||..:..:|||
Zfish   333 EFVERSVERAKNRIVGDPFDLNTEQGPQVDEDQFKKVLGYISSGKRE-GAKLMCGGAPAAERGYF 396

  Fly   439 VNPTIVLSKDPKD--RIMTEEIFGPVLSIYVYKESDLLETMKLVHTSTKFALTGAVFGQDEDFVK 501
            :.||:.  .|.||  .|..|||||||:.|..:|  .|.|.::..:.| |:.|..|||.|:.|  |
Zfish   397 IQPTVF--GDVKDDMTIAREEIFGPVMQILKFK--SLEEVIERANDS-KYGLAAAVFTQNID--K 454

  Fly   502 CALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAG 543
            .......:.||..:||..:...|  |.||||.:.||...:.|
Zfish   455 ANYISHGLRAGTVWINCYNVFGV--QAPFGGYKASGIGRELG 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	140/518 (27%)
aldh2.1	NP_956784.1	ALDH_F1AB_F2_RALDH1	30..510	CDD:143459	142/528 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810