DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh1 and Aldh1l2

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001178707.2	Gene:	Aldh1l2 / 299699	RGDID:	1309458	Length:	923	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	134/588 - (22%)
Similarity:	232/588 - (39%)	Gaps:	108/588 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RMMRSSSSRCSSLQ-QSLLKSSTRCLGSVIPDL--KLKDFPIANEPILGYLKDSKE------RKA 58
            |::.....:|..|| |:......|..|..|..:  :|:......|.::.|:  |||      :..
  Rat   380 RLVEEIRQKCGGLQLQNEDVYMARKFGDFIQKVVRRLRGEDQEAELVVDYV--SKEVNEMTVKMP 442

  Fly    59 LEQALKGTASSCEDIPIVIGGKEYKTPEVRYQVMPHDHQHKLASFYYADKKLIEKAIKTAVET-- 121
            .:..:.|.....||      |:.|.|      :.|.|.. .|....||....:::|:..|.:.
  Rat   443 YQCFINGQFVDAED------GETYAT------INPTDGT-TLCRVSYASLADVDRAVAAAKDAFE 494

  Fly   122 QPKWDRVSIADRLKIWEKAADLM-------ATTYRQDLNAA------TMLGQS------------ 161
            ..:|.|::..||.::..:.||||       ||....|..|.      |.:|.|
  Rat   495 NGEWGRMNARDRGRLMYRLADLMEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCD 559

  Fly   162 KTAIQAEIDSAAELIDFIRMNAYFLKEVTKYQPISENIKVTKNSLRYRGIDGFIAAVSPFNFTAI 226
            |..:..|.::.|.:.|.:.|:             ||..||.            .|.:.|:|:
  Rat   560 KIQVTKEPENQARIHDTLGMS-------------SEEPKVV------------CAIIIPWNY--- 596

  Fly   227 GGNLSYTPALM-----------GNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVF 280
                   |.:|           ||.::.||:....|:.....::..:||.|.||:|.:|..|.|.
  Rat   597 -------PLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELTVKAGFPKGVINIIPGSGGVA 654

  Fly   281 GDTITASPHLAGINFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVT 345
            |..::..|.:..:.||||.....::.|....:     |..:::.|.|||:...|.:..:::..|.
  Rat   655 GQRLSQHPDIRKLGFTGSTSVGKQIMKSCAVS-----NLKKVSLELGGKSPLIIFSDCELDKAVR 714

  Fly   346 STIRSAFEYCGQKCSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRI 410
            ..:.:.|...|:.|.|..|::|.|::..:....:|.|..|:||||..|.|:...........:::
  Rat   715 MGMGAVFFNKGENCIAAGRLFVEEAIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKL 779

  Fly   411 TGYIEHAKKSPNLEILAGGTYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDLLE 475
            ..|.|...|. ...::.||......|:|:.||:....:....:..||.|||::.|..::..|:..
  Rat   780 LQYCETGVKE-GATLVYGGRQVQRPGFFMEPTVFTGVEDHMYLAKEESFGPIMVISKFQNGDIDG 843

  Fly   476 TMKLVHTSTKFALTGAVFGQDEDFVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTND 540
            .::..: :|::.|...||  ..|..|......::.||..:||..:...|..  ||||.:.||...
  Rat   844 VLQRAN-NTEYGLASGVF--TRDISKAMYVSDRLEAGTVFINTYNKTDVAA--PFGGVKQSGFGK 903

  Fly   541 KAG 543
            ..|
  Rat   904 DLG 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	125/547 (23%)
Aldh1l2	NP_001178707.2	FMT_core_FDH_N	23..225	CDD:187716
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..>390	CDD:395435	1/9 (11%)
		ALDH_F1L_FTFDH	438..923	CDD:143458	120/528 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900