DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh1 and Aldh2

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_115792.2	Gene:	Aldh2 / 29539	RGDID:	69219	Length:	519	Species:	Rattus norvegicus

Alignment Length:	451	Identity:	135/451 - (29%)
Similarity:	214/451 - (47%)	Gaps:	41/451 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 DKKLIEKAIK---TAVETQPKWDRVSIADRLKIWEKAADLMA--TTYRQDLNAATMLGQSKTAIQ 166
            :|:.::||:|   .|.:....|.|:..:||.::..:.|||:.  .||   |.|...|...|..:
  Rat    74 NKEDVDKAVKAARAAFQLGSPWRRMDASDRGRLLYRLADLIERDRTY---LAALETLDNGKPYV- 134

  Fly   167 AEIDSAAELIDFIRMNAYFLKEVTKYQPISENIKVTKNSLRYRGID--GFIAAVSPFNFTAIGGN 229
              |....:|...::...|:.....||.  .:.|.:..:...|...:  |....:.|:||..:...
  Rat   135 --ISYLVDLDMVLKCLRYYAGWADKYH--GKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQA 195

  Fly   230 LSYTPAL-MGNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAGI 293
            ....||| .||.|:.|.::...|:...:..:::|||.|.||||.||..||..|..|.:...:..:
  Rat   196 WKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKV 260

  Fly   294 NFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQK 358
            .||||....:.:....|::     |..|:|.|.|||:.:.|.:.||::..|.....:.|...||.
  Rat   261 AFTGSTEVGHLIQVAAGSS-----NLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQC 320

  Fly   359 CSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHAKKSPNL 423
            |.|.||.:|.|.::.:..|..|..|....:|:..|..:.....:|:..||:|.|||:..::. ..
  Rat   321 CCAGSRTFVQEDVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKILGYIKSGQQE-GA 384

  Fly   424 EILAGGTYSDSKGYFVNPTIVLSKDPKD--RIMTEEIFGPVLSIYVYKESDLLETMKLVHTSTKF 486
            ::|.||..:..:|||:.||:.  .|.||  .|..|||||||:.|..:|   .:|.:.....::|:
  Rat   385 KLLCGGGAAADRGYFIQPTVF--GDVKDGMTIAKEEIFGPVMQILKFK---TIEEVVGRANNSKY 444

  Fly   487 ALTGAVFGQDED---FVKCALQEFKMAAGNFYINDKSTGSVVG-QQPFGGGRMSGTNDKAG 543
            .|..|||.:|.|   ::..|||     ||..:||   ...|.| |.||||.:|||:..:.|
  Rat   445 GLAAAVFTKDLDKANYLSQALQ-----AGTVWIN---CYDVFGAQSPFGGYKMSGSGRELG 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	135/451 (30%)
Aldh2	NP_115792.2	ALDH_F1AB_F2_RALDH1	33..513	CDD:143459	135/451 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810