DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh1 and Aldh7a1

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001258034.1	Gene:	Aldh7a1 / 291450	RGDID:	1308614	Length:	539	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	128/571 - (22%)
Similarity:	227/571 - (39%)	Gaps:	92/571 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRMMRS---SSSRCSSLQQSLLKSSTRCLGSVIPDLKLKDFPIANEPILGYLKDSKERKALEQA 62
            |||:.|.   .:.:.|.|  |.|.|....|.|.:         :.:.|...:|:|...|:..|..
  Rat     1 MLRLARPLCVQTVKASKL--SRLWSRPAALMSTL---------LIHHPQYAWLQDLGLREDNEGV 54

  Fly    63 LKGTASSCEDIPIVIGGKEYKTPEVRYQVMPHDHQHKLASFYYADKKLIEKAIKTAVETQPKWDR 127
            ..|:          .||:    .||.....|.::: .:|....|..|..|:.|..|.:....|..
  Rat    55 FNGS----------WGGR----GEVITTYCPANNE-PIARVRQASMKDYEETIGKAKKAWNIWAD 104

  Fly   128 VSIADRLKIWEKAADLMATTYRQDLNAATMLGQSKTAIQ--AEIDSAAELIDFI----RM----- 181
            :....|.:|..|..|.:.... |.|.....|...|..::  .|:....::.|:.    ||
  Rat   105 IPAPKRGEIVRKIGDALREKI-QLLGRLVSLEMGKILVEGIGEVQEYVDVCDYAAGLSRMIGGPT 168

  Fly   182 -----NAYFLKEVTKYQPISENIKVTKNSLRYRGIDGFIAAVSPFNF-TAIGGNLSYTPALMGNG 240
                 ..:.|.|  ::.|:                 |.:..::.||| .|:.|..:....:.||.
  Rat   169 LPSERPGHALME--QWNPL-----------------GLVGIITAFNFPVAVFGWNNAIALITGNV 214

  Fly   241 VLWKPSDTAMLSN----WIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAGINFTGSVPT 301
            .|||.:.|..|.:    .||.|::.:..:| |.:..:...|...|..:.....:..::||||.
  Rat   215 CLWKGAPTTSLVSIAVTKIIAKVLEDNLLP-GAICSLTCGGADMGTAMARDERVNLLSFTGST-- 276

  Fly   302 FNRLWKQVGNNIDNYV--NFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQKCSACSR 364
                  |||..:...|  .|.:...|.||.|.......||:..|:.|.:.:|....||:|:...|
  Rat   277 ------QVGKQVALMVQERFGKSLLELGGNNAIIAFEDADLSLVLPSALFAAVGTAGQRCTTVRR 335

  Fly   365 MYVPESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHAKKSPNLEILAGG 429
            :::.||:..::.:.|....:::::|:..|.:.....:...:|.......:|.|||... .::.||
  Rat   336 LFLHESIHDEVVDRLKNAYSQIRVGNPWDPNILYGPLHTKQAVSMFVQAVEEAKKEGG-TVVYGG 399

  Fly   430 TYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYK-ESDLLETMKLVHTSTKFALTGAVF 493
            ...|..|.:|.||||........|:.:|.|.|:|.::.:| |.::.|.    :...|..|:.::|
  Rat   400 KVMDHPGNYVEPTIVTGLVHDAPIVHKETFAPILYVFKFKNEEEVFEW----NNEVKQGLSSSIF 460

  Fly   494 GQDEDFVKCALQEFKMAAGNFYINDKSTGSVV-----GQQPFGGGRMSGTN 539
            .:|...:...|.......|...:|..::|:.:     |::..||||.||::
  Rat   461 TKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSD 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	117/528 (22%)
Aldh7a1	NP_001258034.1	ALDH_F7_AASADH	53..527	CDD:143448	112/508 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900