DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh1 and Aldh8a1

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_848828.1	Gene:	Aldh8a1 / 237320	MGIID:	2653900	Length:	487	Species:	Mus musculus

Alignment Length:	538	Identity:	137/538 - (25%)
Similarity:	231/538 - (42%)	Gaps:	75/538 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 KERKALEQALKGTASSCEDIPIVIGGKEYKTPEVRYQVMPHDHQHKLASFYYADKKLIEKAIKTA 118
            :|...||..:.|....|..   .|...:..|.|| |..:|:           :.|:.||.|::.|
Mouse     5 RELLMLENFIGGKFLPCNS---YIDSYDPSTGEV-YCKVPN-----------SGKEEIEAAVEAA 54

  Fly   119 VETQPKWDRVSIADRLKIWEKAADLMATTYRQDLNAATMLGQSKTAIQAE-IDSAAELID---FI 179
            .|..|.|...|..:|..:..:.||::..:. ::|..|....|.||...|. :|....:::   |.
Mouse    55 REAFPAWSSRSPQERSLVLNRLADVLEQSL-EELAQAESKDQGKTLTLARTMDIPRSVLNFRFFA 118

  Fly   180 RMNAYFLKEVTKYQPISENIKVTKNSLRYR-----GIDGFIAAVSPFNFTAIGGNLSYTPAL-MG 238
            ..|.:.:.|.|:...:        ..:.|.     ||.|.|   ||:|...........||: .|
Mouse   119 SSNLHHVSECTQMSHL--------GCMHYTVRTPVGIAGLI---SPWNLPLYLLTWKIAPAIAAG 172

  Fly   239 NGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAGINFTGSVPTFN 303
            |.|:.|||:...::.|:..|::.:||||.||:|.|...||..|:.:.:.|.:..|:||||.||..
Mouse   173 NTVIAKPSEMTSVTAWMFCKLLDKAGVPPGVINIVFGTGPRVGEALVSHPEVPLISFTGSQPTAE 237

  Fly   304 RLWKQVGNNIDNYVNFP---RLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQKCSACSRM 365
            |:         ..::.|   :|:.|.||||...|...|::|..:.:|:||:|...|:.|...||:
Mouse   238 RI---------TQLSAPHCKKLSLELGGKNPAIIFEDANLEECIPATVRSSFANQGEICLCTSRI 293

  Fly   366 YVPESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHAKKSPNLEILAGG- 429
            :|..|::.:..:..|....|.|:|...|.|:...|:|.....:::..|:..| ::....||.|.
Mouse   294 FVQRSIYSEFLKRFVEATRKWKVGVPSDPSANMGALISKAHLEKVRSYVLKA-QTEGARILCGEG 357

  Fly   430 ------TYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDLLETMKLVHTSTKFAL 488
                  ...:..|||:.||::.....:.|.|||||||||..:..:...:.:.|..   .|.::.|
Mouse   358 VDQLSLPLRNQAGYFMLPTVITDIKDESRCMTEEIFGPVTCVVPFDSEEEVITRA---NSVRYGL 419

  Fly   489 TGAVFGQDEDFVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAGGPHYILRWTS 553
            ...|:.:|...:....:  |:.:|..:.|......:  ..||||.:.||...:.....|
Mouse   420 AATVWSKDVGRIHRVAK--KLQSGLVWTNCWLIREL--NLPFGGMKSSGIGREGAKDSY------ 474

  Fly   554 PQSIKETFVPLRDVNYPY 571
                 :.|..::.:...|
Mouse   475 -----DFFTEIKTITIKY 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	136/528 (26%)
Aldh8a1	NP_848828.1	ALDH_F8_HMSADH	27..485	CDD:143412	130/509 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810