DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P5CDh1 and ALDH9A1

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_000687.3	Gene:	ALDH9A1 / 223	HGNCID:	412	Length:	518	Species:	Homo sapiens

Alignment Length:	458	Identity:	122/458 - (26%)
Similarity:	216/458 - (47%)	Gaps:	41/458 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 LASFYYADKKLIEKAIKTAVETQPKWDRVSIADRLKIWEKAADLMATTYRQDLNAATM--LGQSK 162
            :|:|..:.:|.:..|::.|......|.:.|..:|.:|..:||.::..  |:| ..|||  :...|
Human    64 IATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRE--RED-EIATMECINNGK 125

  Fly   163 TAIQA--EIDSAAELIDFIRMNAYFLKEVTKYQPISENIKVTKNSLRY--RGIDGFIAAVSPFNF 223
            :..:|  :||.:.:.:::....|..:        ..|:|::...|..|  |...|....:..:|:
Human   126 SIFEARLDIDISWQCLEYYAGLAASM--------AGEHIQLPGGSFGYTRREPLGVCVGIGAWNY 182

  Fly   224 TAIGGNLSYTPAL-MGNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITAS 287
            .....:....||| .||.:::|||....:|..::.:|..|||||.|:.|.|.. |...|..:...
Human   183 PFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQH 246

  Fly   288 PHLAGINFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAF 352
            |.:|.::|||||||..::.:.....|      ..:|.|.|||:...|.:..|:.:.|...:.:.|
Human   247 PDVAKVSFTGSVPTGMKIMEMSAKGI------KPVTLELGGKSPLIIFSDCDMNNAVKGALMANF 305

  Fly   353 EYCGQKCSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHA 417
            ...||.|...:|::|.:.:..:..|.:|.:..::||||.....:....:|:....:|:.|:::.|
Human   306 LTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVA 370

  Fly   418 KKSPNLEILAGGTY---SDSK---GYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVY-KESDLLE 475
            |:. ..::|.||..   .|.|   ||::.|.::.:.......:.|||||||:||..: .|:::||
Human   371 KEQ-GAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLE 434

  Fly   476 TMKLVHTSTKFALTGAVFGQDEDFVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTND 540
            ..    ..|.|.|...||.:|.......:.|  :.||..:||:.:...|  :.||||.:.||...
Human   435 RA----NDTTFGLAAGVFTRDIQRAHRVVAE--LQAGTCFINNYNVSPV--ELPFGGYKKSGFGR 491

  Fly   541 KAG 543
            :.|
Human   492 ENG 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	122/458 (27%)
ALDH9A1	NP_000687.3	ALDH_F9_TMBADH	55..512	CDD:143409	122/458 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810