DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh1 and ALDH1A3

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_000684.2	Gene:	ALDH1A3 / 220	HGNCID:	409	Length:	512	Species:	Homo sapiens

Alignment Length:	504	Identity:	152/504 - (30%)
Similarity:	231/504 - (45%)	Gaps:	52/504 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 GKEYKT--PEVRYQVMPHDHQHKLASFYYADKKLIEKAI---KTAVETQPKWDRVSIADRLKIWE 138
            ||::.|  |..|.|:...:.         .||..::||:   :.|.:....|.|:....|.::..
Human    46 GKKFATCNPSTREQICEVEE---------GDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLH 101

  Fly   139 KAADLMATTYRQDLNAATMLGQSKTAIQAEIDSAAELIDFIRMNAYFLKEVTKYQ----PISENI 199
            :.|||:... |..|.|...:...|..:.|..   .:|...||...||.....|.|    |..:|:
Human   102 QLADLVERD-RATLAALETMDTGKPFLHAFF---IDLEGCIRTLRYFAGWADKIQGKTIPTDDNV 162

  Fly   200 KVTKNSLRYRGIDGFIAAVSPFNFTAIGGNLSYTPAL-MGNGVLWKPSDTAMLSNWIIFKIMREA 263
            ..   ..|:..| |...|::|:||..:.......||| .||.::.||::...|:...:..:::||
Human   163 VC---FTRHEPI-GVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEA 223

  Fly   264 GVPDGVVNFVPADGPVFGDTITASPHLAGINFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECGG 328
            |.|.||||.||..||..|..|::.|.:..|.||||... .:|.|:..:.    .|..|:|.|.||
Human   224 GFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEV-GKLVKEAASR----SNLKRVTLELGG 283

  Fly   329 KNFHFIHASADVESVVTSTIRSAFEYCGQKCSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQD 393
            ||...:.|.||::..|....:..|...||.|:|.||::|.|.::.:.....|..|.|..:||..|
Human   284 KNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFD 348

  Fly   394 FSSFTSAVIDDKAFKRITGYIEHAKKSPNLEILAGGTYSDSKGYFVNPTIVLSKDPKDRIMTEEI 458
            ..:.....||.|.|.:|...||..||. ..::..||:..:.||.|:.||:........||..|||
Human   349 VKTEQGPQIDQKQFDKILELIESGKKE-GAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEI 412

  Fly   459 FGPVLSIYVYKESDLLETMKLVHTSTKFALTGAVFGQDEDFVKCALQEFKMA----AGNFYINDK 519
            ||||..|..:|..:  |.:|..: ||.:.||.|||.::.|      :..|:|    :|..:||
Human   413 FGPVQPILKFKSIE--EVIKRAN-STDYGLTAAVFTKNLD------KALKLASALESGTVWIN-- 466

  Fly   520 STGSVVGQQPFGGGRMSGTNDKAGGPHYILRWTSPQSIKETFVPLRDVN 568
            ...::..|.||||.:||| |.:..|.:.:..:|   .:|...:.|.|.|
Human   467 CYNALYAQAPFGGFKMSG-NGRELGEYALAEYT---EVKTVTIKLGDKN 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	149/497 (30%)
ALDH1A3	NP_000684.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
ALDH1A3	NP_000684.2	ALDH_F1AB_F2_RALDH1	26..506	CDD:143459	149/497 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810