Protein Alignment P5CDh1 and ALDH1B1

DIOPT Version :10

• Sequence 1: NP_649368.2
• Gene: P5CDh1 / 40434
• FlyBaseID: FBgn0037138
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: XP_011516104.2
• Gene: ALDH1B1 / 219
• HGNCID: 407
• Length: 564
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 149/568 - (26%)
• Similarity: 244/568 - (42%)
• Gaps: 101/568 - (17%)

  Fly     4 MMRSSSSRCSSLQ-QSLLKSSTRCLGSVI--PDLKLKDFPIANEPILGYLKDSKERKALEQALKG 65
            |:|..:.|..||| ::...||...|.|.|  ||:......|.||     .:|:..:|........
Human    48 MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNE-----WQDAVSKKTFPTVNPT 107

  Fly    66 TASSCEDIPIVIGGKEYKTPEVRYQVMPHDHQHKLASFYYADKKLIEKAIKTAVET----QPKWD 126
            |.                      :|:.|..:        .|:..:::|:|.|.|.    .| |.
Human   108 TG----------------------EVIGHVAE--------GDRADVDRAVKAAREAFRLGSP-WR 141

  Fly   127 RVSIADRLKIWEKAADLMATTYRQDLNAATMLGQSKTAIQAEIDSAAELIDFIRMNAYFL----- 186
            |:..::|.::..:.|||:... |..|.:...|...|...::   .|.:|.:.|::..||.
Human   142 RMDASERGRLLNRLADLVERD-RVYLASLETLDNGKPFQES---YALDLDEVIKVYRYFAGWADK 202

  Fly   187 ---KEV---------TKYQPISENIKVTKNSLRYRGIDGFIAAVSPFNFTAIGGNLSYTPAL-MG 238
               |.:         |:::|:                 |....:.|:||..:.......||| .|
Human   203 WHGKTIPMDGQHFCFTRHEPV-----------------GVCGQIIPWNFPLVMQGWKLAPALATG 250

  Fly   239 NGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAGINFTGSVPTFN 303
            |.|:.|.::...||...:..:::|||.|.||||.:...||..|..|.....:..:.||||....:
Human   251 NTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGH 315

  Fly   304 RLWKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQKCSACSRMYVP 368
            .:.|..|::     |..|:|.|.|||:...:.|.||:|..|.....:.|...||.|.|.||.:|.
Human   316 LIQKAAGDS-----NLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVE 375

  Fly   369 ESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHAKKSPNLEILAGGTYSD 433
            ||::.:..|..|.:|.:.|:|:..:..:.....:|.:.|:|:.|||:..:|. ..::|.||....
Human   376 ESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKE-GAKLLCGGERFG 439

  Fly   434 SKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDLLETMKLVHTSTKFALTGAVFGQDED 498
            .:|:|:.||:........||..|||||||..::.:|:   :|.:.....:|::.|..|||.:|.|
Human   440 ERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKK---IEEVVERANNTRYGLAAAVFTRDLD 501

  Fly   499 ---FVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAG 543
               :...|||     ||..::|  :...|....||||.:.||...:.|
Human   502 KAMYFTQALQ-----AGTVWVN--TYNIVTCHTPFGGFKESGNGRELG 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_649368.2	ALDH_F4-17_P5CDH	41..563	CDD:143441	136/528 (26%)
ALDH1B1	XP_011516104.2	ALDH_F1AB_F2_RALDH1	78..558	CDD:143459	138/538 (26%)