DRSC/TRiP Functional Genomics Resources

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Protein Alignment P5CDh1 and ALDH2

DIOPT Version :10

Sequence 1:NP_649368.2 Gene:P5CDh1 / 40434 FlyBaseID:FBgn0037138 Length:574 Species:Drosophila melanogaster
Sequence 2:NP_000681.2 Gene:ALDH2 / 217 HGNCID:404 Length:517 Species:Homo sapiens


Alignment Length:449 Identity:133/449 - (29%)
Similarity:208/449 - (46%) Gaps:37/449 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   107 DKKLIEKAIK---TAVETQPKWDRVSIADRLKIWEKAADLMA--TTYRQDLNAATMLGQSKTAIQ 166
            ||:.::||:|   .|.:....|.|:..:.|.::..:.|||:.  .||   |.|...|...|..: 
Human    72 DKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTY---LAALETLDNGKPYV- 132

  Fly   167 AEIDSAAELIDFIRMNAYFLKEVTKYQPISENIKVTKNSLRYRGID--GFIAAVSPFNFTAIGGN 229
              |....:|...::...|:.....||.  .:.|.:..:...|...:  |....:.|:||..:...
Human   133 --ISYLVDLDMVLKCLRYYAGWADKYH--GKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQA 193

  Fly   230 LSYTPAL-MGNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAGI 293
            ....||| .||.|:.|.::...|:...:..:::|||.|.||||.||..||..|..|.:...:..:
Human   194 WKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKV 258

  Fly   294 NFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQK 358
            .||||......:....|::     |..|:|.|.|||:.:.|.:.||::..|.....:.|...||.
Human   259 AFTGSTEIGRVIQVAAGSS-----NLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQC 318

  Fly   359 CSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHAKKSPNL 423
            |.|.||.:|.|.::.:..|..|..|....:|:..|..:.....:|:..||:|.|||...|:. ..
Human   319 CCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQE-GA 382

  Fly   424 EILAGGTYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDLLETMKLVHTSTKFAL 488
            ::|.||..:..:|||:.||:.........|..|||||||:.|..:|..:  |.:...:.|| :.|
Human   383 KLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIE--EVVGRANNST-YGL 444

  Fly   489 TGAVFGQDED---FVKCALQEFKMAAGNFYINDKSTGSVVG-QQPFGGGRMSGTNDKAG 543
            ..|||.:|.|   ::..|||     ||..::|   ...|.| |.||||.:|||:..:.|
Human   445 AAAVFTKDLDKANYLSQALQ-----AGTVWVN---CYDVFGAQSPFGGYKMSGSGRELG 495

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
P5CDh1NP_649368.2 ALDH_F4-17_P5CDH 41..563 CDD:143441 133/449 (30%)
ALDH2NP_000681.2 SIFI-degron. /evidence=ECO:0000269|PubMed:38297121 9..24
ALDH_F1AB_F2_RALDH1 31..511 CDD:143459 133/449 (30%)
Blue background indicates that the domain is not in the aligned region.

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