Protein Alignment P5CDh1 and ALDH1A1

DIOPT Version :10

• Sequence 1: NP_649368.2
• Gene: P5CDh1 / 40434
• FlyBaseID: FBgn0037138
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_000680.2
• Gene: ALDH1A1 / 216
• HGNCID: 402
• Length: 501
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 140/514 - (27%)
• Similarity: 229/514 - (44%)
• Gaps: 72/514 - (14%)

  Fly    66 TASSCEDIPIVIGGKEYKTPEV-------------RYQVMPHDHQHKLASFYYADKKLIEKAIKT 117
            ::|...|:|:::...:.:..::             ::.|.....:.:|......||:.::||:|.
Human     2 SSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKA 66

  Fly   118 ---AVETQPKWDRVSIADRLKIWEKAADLMATTYRQDLNAATM--LGQSKTAIQAEIDSAAELID 177
               |.:....|..:..::|.::..|.|||:.   |..|..|||  :...|....|.::..|..|.
Human    67 ARQAFQIGSPWRTMDASERGRLLYKLADLIE---RDRLLLATMESMNGGKLYSNAYLNDLAGCIK 128

  Fly   178 FIRMNAYFLKEV--------------TKYQPISENIKVTKNSLRYRGIDGFIAAVSPFNFTAIGG 228
            .:|..|.:..::              |:::||                 |....:.|:||..:..
Human   129 TLRYCAGWADKIQGRTIPIDGNFFTYTRHEPI-----------------GVCGQIIPWNFPLVML 176

  Fly   229 NLSYTPAL-MGNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAG 292
            .....||| .||.|:.||::...|:...:..:::|||.|.||||.||..||..|..|::...:..
Human   177 IWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDK 241

  Fly   293 INFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQ 357
            :.||||......:.:..|.:     |..|:|.|.|||:...:.|.||:::.|.......|.:.||
Human   242 VAFTGSTEVGKLIKEAAGKS-----NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQ 301

  Fly   358 KCSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHAKKSPN 422
            .|.|.||::|.||::.:.....|..|.|..:|:...........||.:.:.:|...||..||. .
Human   302 CCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKE-G 365

  Fly   423 LEILAGGTYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDLLETMKLVHTSTKFA 487
            .::..||....:|||||.||:..:...:.||..|||||||..|..:|..|  :.:|..: :|.:.
Human   366 AKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLD--DVIKRAN-NTFYG 427

  Fly   488 LTGAVFGQDED---FVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAG 543
            |:..||.:|.|   .:..|||     ||..::|  ..|.|..|.||||.:|||...:.|
Human   428 LSAGVFTKDIDKAITISSALQ-----AGTVWVN--CYGVVSAQCPFGGFKMSGNGRELG 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_649368.2	ALDH_F4-17_P5CDH	41..563	CDD:143441	140/514 (27%)
ALDH1A1	NP_000680.2	ALDH_F1AB_F2_RALDH1	15..495	CDD:143459	137/501 (27%)
		Mediates interaction with PRMT3. /evidence=ECO:0000269|PubMed:33495566	336..501		52/155 (34%)