DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh1 and ALDH1A1

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_000680.2	Gene:	ALDH1A1 / 216	HGNCID:	402	Length:	501	Species:	Homo sapiens

Alignment Length:	514	Identity:	140/514 - (27%)
Similarity:	229/514 - (44%)	Gaps:	72/514 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 TASSCEDIPIVIGGKEYKTPEV-------------RYQVMPHDHQHKLASFYYADKKLIEKAIKT 117
            ::|...|:|:::...:.:..::             ::.|.....:.:|......||:.::||:|.
Human     2 SSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKA 66

  Fly   118 ---AVETQPKWDRVSIADRLKIWEKAADLMATTYRQDLNAATM--LGQSKTAIQAEIDSAAELID 177
               |.:....|..:..::|.::..|.|||:.   |..|..|||  :...|....|.::..|..|.
Human    67 ARQAFQIGSPWRTMDASERGRLLYKLADLIE---RDRLLLATMESMNGGKLYSNAYLNDLAGCIK 128

  Fly   178 FIRMNAYFLKEV--------------TKYQPISENIKVTKNSLRYRGIDGFIAAVSPFNFTAIGG 228
            .:|..|.:..::              |:::||                 |....:.|:||..:..
Human   129 TLRYCAGWADKIQGRTIPIDGNFFTYTRHEPI-----------------GVCGQIIPWNFPLVML 176

  Fly   229 NLSYTPAL-MGNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAG 292
            .....||| .||.|:.||::...|:...:..:::|||.|.||||.||..||..|..|::...:..
Human   177 IWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDK 241

  Fly   293 INFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQ 357
            :.||||......:.:..|.:     |..|:|.|.|||:...:.|.||:::.|.......|.:.||
Human   242 VAFTGSTEVGKLIKEAAGKS-----NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQ 301

  Fly   358 KCSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHAKKSPN 422
            .|.|.||::|.||::.:.....|..|.|..:|:...........||.:.:.:|...||..||. .
Human   302 CCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKE-G 365

  Fly   423 LEILAGGTYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDLLETMKLVHTSTKFA 487
            .::..||....:|||||.||:..:...:.||..|||||||..|..:|..|  :.:|..: :|.:.
Human   366 AKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLD--DVIKRAN-NTFYG 427

  Fly   488 LTGAVFGQDED---FVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAG 543
            |:..||.:|.|   .:..|||     ||..::|  ..|.|..|.||||.:|||...:.|
Human   428 LSAGVFTKDIDKAITISSALQ-----AGTVWVN--CYGVVSAQCPFGGFKMSGNGRELG 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	140/514 (27%)
ALDH1A1	NP_000680.2	ALDH_F1AB_F2_RALDH1	15..495	CDD:143459	137/501 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810