DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P5CDh1 and Aldh4a1

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_780647.3	Gene:	Aldh4a1 / 212647	MGIID:	2443883	Length:	562	Species:	Mus musculus

Alignment Length:	563	Identity:	327/563 - (58%)
Similarity:	419/563 - (74%)	Gaps:	11/563 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SLQQSLLKSSTRCLGSVIPDLKLK---DFPIANEPILGYLKDSKERKALEQALKGTASSCEDIPI 75
            ||::|||..:.|..|     |:.|   ...:.|||||.:.:.|.||.||::|||......|.||.
Mouse     6 SLRRSLLSHAWRGAG-----LRWKHTSSLKVTNEPILAFSQGSPERDALQKALKDLKGQMEAIPC 65

  Fly    76 VIGGKEYKTPEVRYQVMPHDHQHKLASFYYADKKLIEKAIKTAVETQPKWDRVSIADRLKIWEKA 140
            |:|.:|..|.:::||:.|.:|.||:|.|.||||.|:.:||..|:..:.:||...:|||.:::.||
Mouse    66 VVGDEEVWTSDIQYQLSPFNHAHKVAKFCYADKALLNRAIDAALAARKEWDLKPMADRAQVFLKA 130

  Fly   141 ADLMATTYRQDLNAATMLGQSKTAIQAEIDSAAELIDFIRMNAYFLKEVTKYQPISENIKVTKNS 205
            ||:::...|.::.|.||:||.||.||||||:|||||||.|.||.|..|:...||||  :..:.|.
Mouse   131 ADMLSGPRRAEVLAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKFAVELEGEQPIS--VPPSTNH 193

  Fly   206 LRYRGIDGFIAAVSPFNFTAIGGNLSYTPALMGNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVV 270
            ..|||::||:||:||||||||||||:..||||||.|||||||||||:::.:::|:||||:|..::
Mouse   194 TVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNII 258

  Fly   271 NFVPADGPVFGDTITASPHLAGINFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECGGKNFHFIH 335
            .|||||||.||||:|:|.||.|||||||||||..||:||..|:|.:..||||.||||||||||:|
Mouse   259 QFVPADGPTFGDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVH 323

  Fly   336 ASADVESVVTSTIRSAFEYCGQKCSACSRMYVPESLWPQIKEGLVCEAAKLKIGD-VQDFSSFTS 399
            :||||:|||:.|:||||||.|||||||||:|||:|||||||..|:.|.:::|:|| .:||.:|.|
Mouse   324 SSADVDSVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFS 388

  Fly   400 AVIDDKAFKRITGYIEHAKKSPNLEILAGGTYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLS 464
            ||||.|||.||..::|||:.||:|.|||||..::|.||:|.|.|:.||||::.||.||||||||:
Mouse   389 AVIDAKAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKEEIFGPVLT 453

  Fly   465 IYVYKESDLLETMKLVHTSTKFALTGAVFGQDEDFVKCALQEFKMAAGNFYINDKSTGSVVGQQP 529
            :|||.:....||::||.::|.:.||||||.||:..|:.|.:..:.||||||||||||||||||||
Mouse   454 VYVYPDDKYRETLQLVDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYINDKSTGSVVGQQP 518

  Fly   530 FGGGRMSGTNDKAGGPHYILRWTSPQSIKETFVPLRDVNYPYM 572
            |||.|.||||||.|||||||||||||.||||..||.|..|.||
Mouse   519 FGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWRYSYM 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	312/522 (60%)
Aldh4a1	NP_780647.3	ALDH_F4-17_P5CDH	31..552	CDD:143441	312/522 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849644
Domainoid	1	1.000	590	1.000	Domainoid score	I202
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6081
Inparanoid	1	1.050	656	1.000	Inparanoid score	I771
Isobase	1	0.950	-	0	Normalized mean entropy	S619
OMA	1	1.010	-	-		QHG63568
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004722
OrthoInspector	1	1.000	-	-		oto95137
orthoMCL	1	0.900	-	-		OOG6_102275
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1040
SonicParanoid	1	1.000	-	-		X3320
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.640