DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh1 and alh-3

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_502054.2	Gene:	alh-3 / 177999	WormBaseID:	WBGene00000109	Length:	908	Species:	Caenorhabditis elegans

Alignment Length:	529	Identity:	136/529 - (25%)
Similarity:	231/529 - (43%)	Gaps:	73/529 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 IANEPILGYLKDSKERKALEQALKGTASSCEDIPIVIGGKEYKT--PEVRYQV--MPHDHQHKLA 101
            :..:||:..:.:.:.:...:|.:.|......|      |:.:||  |.....:  :|      ||
Worm   410 VTYDPIVLNVNNMELKFPHDQFIDGKFVGSSD------GRTFKTINPATEKPICELP------LA 462

  Fly   102 SFYYADKKLIEKAIKTAVETQPKWDRVSIADRLKIWEKAADLM-------ATTYRQDLNAATMLG 159
            :....|:.:  :|.|.|.| :.:|.::|..:|.|...|.|:||       ||....|..|...|.
Worm   463 TVADVDRAV--RAAKKAFE-RGEWRQMSARERGKRLYKLAELMEEHKEELATLESLDAGAVYTLA 524

  Fly   160 QSKTAIQAEIDSAAELIDFIRMNAYFLKEVTKYQ----PISENIKVTKN-SLRYRGIDGFIAAVS 219
             .||.:...||          :..||.....|.|    ||| |.:..|| .|..|...|.:..::
Worm   525 -LKTHVGMSID----------VWRYFAGWCDKIQGKTIPIS-NARPNKNLCLTLREPIGVVGLIT 577

  Fly   220 PFNFTAIGGNLSYTPA---LMGNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFG 281
            |:|:..:  .||:..|   ..||.|:.||:....|:.....::...||:|.||:|.|...|.:.|
Worm   578 PWNYPLM--MLSWKMAACLAAGNTVVHKPAQVTPLTALKFAELSVLAGIPPGVINIVTGSGSLVG 640

  Fly   282 DTITASPHLAGINFTGSVPTFNRLWKQVGNNIDNYV---NFPRLTGECGGKNFHFIHASADVESV 343
            :.:||.|.:..|.||||.        ::|..:....   |..:::.|.|||:...|.|.||:|..
Worm   641 NRLTAHPDVRKIGFTGST--------EIGATVMESCAKSNIKKVSLELGGKSPLIIFADADLEKA 697

  Fly   344 VTSTIRSAFEYCGQKCSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFK 408
            |.....:.|...|:.|.|..|:::.:|:.....:.||.||.:.:|||..|.|:............
Worm   698 VKQACGAVFFNKGENCIAAGRVFIAKSIHDDFVKKLVEEAKQYQIGDPLDRSTAHGPQNHLAHLN 762

  Fly   409 RITGYIEHAKKSPNLEILAGGTYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDL 473
            ::..|:|.| .:...::..||...:.:|.:..|||:.:.|.::...:||.|||::.:..:.:.|:
Worm   763 KLVEYVEKA-VAGGAKVEVGGKRLEREGLYFPPTILSNIDDENFAASEESFGPIMCVSSFDDDDI 826

  Fly   474 LETMKLVHTSTKFALTGAVFGQDEDFVKCALQEFKMA----AGNFYINDKSTGSVVGQQPFGGGR 534
            .:.::..: .|:|.|...||.:|..      :..::|    ||..::|......|..  ||||.:
Worm   827 EDVLRRAN-DTEFGLAAGVFTRDSS------KSLRVAEALHAGTVFVNTYQKTDVAA--PFGGFK 882

  Fly   535 MSGTNDKAG 543
            .||.....|
Worm   883 QSGFGKDMG 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	136/529 (26%)
alh-3	NP_502054.2	fmt	1..318	CDD:273088
		FMT_core_FDH_N	1..209	CDD:187716
		FDH_Hydrolase_C	214..315	CDD:187731
		PP-binding	335..393	CDD:278949
		ALDH-SF	423..908	CDD:299846	134/516 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810