DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh1 and ALDH1L2

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001029345.2	Gene:	ALDH1L2 / 160428	HGNCID:	26777	Length:	923	Species:	Homo sapiens

Alignment Length:	581	Identity:	136/581 - (23%)
Similarity:	239/581 - (41%)	Gaps:	94/581 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RMMRSSSSRCS--SLQQSLLKSSTRCLG---SVIPDLKLKDFPIANEPILGYLKDSKE------R 56
            |::.....:|.  .||...:..:|:..|   .|:..|:.:|..:  |.::.|:  |||      :
Human   380 RLVEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGEDQEV--ELVVDYI--SKEVNEIMVK 440

  Fly    57 KALEQALKGTASSCEDIPIVIGGKEYKTPEVRYQVMPHDHQHKLASFYYADKKLIEKAIKTAVET 121
            ...:..:.|..:..:|      ||.|.|      :.|.|.. .:....||....::||:..|.:.
Human   441 MPYQCFINGQFTDADD------GKTYDT------INPTDGS-TICKVSYASLADVDKAVAAAKDA 492

  Fly   122 --QPKWDRVSIADRLKIWEKAADL-------MATTYRQDLNAATMLGQSKTAIQAEIDSAAELID 177
              ..:|.|::..:|.::..:.|||       :||....|..|...|     |::..|..:.:..
Human   493 FENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTL-----ALKTHIGMSVQTF- 551

  Fly   178 FIRMNAYFLKEVTKYQ----PISE-----NIKVTKNSLRYRGIDGFIAAVSPFNFTAIGGNLSYT 233
                 .||.....|.|    ||::     |:..||....     |..|.:.|:|:
Human   552 -----RYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPL-----GVCAIIIPWNY---------- 596

  Fly   234 PALM-----------GNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITAS 287
            |.:|           ||.::.||:....|:.....::..:||.|.||:|.:|..|.:.|..::..
Human   597 PLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEH 661

  Fly   288 PHLAGINFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAF 352
            |.:..:.||||.|...::.|....:     |..:::.|.|||:...|....:::..|...:.:.|
Human   662 PDIRKLGFTGSTPIGKQIMKSCAVS-----NLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVF 721

  Fly   353 EYCGQKCSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHA 417
            ...|:.|.|..|::|.||:..:....:|.|..|:||||..|.|:...........:::..|.|..
Human   722 FNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETG 786

  Fly   418 KKSPNLEILAGGTYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDLLETMKLVHT 482
            .|. ...::.||......|:|:.||:....:....:..||.|||::.|..::..|:...::..:
Human   787 VKE-GATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRAN- 849

  Fly   483 STKFALTGAVFGQDEDFVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAG 543
            ||::.|...||.:|.:  |......|:.||..:||..:...|..  ||||.:.||.....|
Human   850 STEYGLASGVFTRDIN--KAMYVSEKLEAGTVFINTYNKTDVAA--PFGGVKQSGFGKDLG 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	127/538 (24%)
ALDH1L2	NP_001029345.2	Fmt	22..326	CDD:223301
		FMT_core_FDH_N	23..225	CDD:187716
		GART	23..225
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..>390	CDD:278949	1/9 (11%)
		Aldehyde dehydrogenase	438..923		122/519 (24%)
		ALDH_F1L_FTFDH	439..923	CDD:143458	122/518 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810