DRSC/TRiP Functional Genomics Resources

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Protein Alignment P5CDh1 and ALDH1L2

DIOPT Version :10

Sequence 1:NP_649368.2 Gene:P5CDh1 / 40434 FlyBaseID:FBgn0037138 Length:574 Species:Drosophila melanogaster
Sequence 2:NP_001029345.2 Gene:ALDH1L2 / 160428 HGNCID:26777 Length:923 Species:Homo sapiens


Alignment Length:581 Identity:136/581 - (23%)
Similarity:239/581 - (41%) Gaps:94/581 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 RMMRSSSSRCS--SLQQSLLKSSTRCLG---SVIPDLKLKDFPIANEPILGYLKDSKE------R 56
            |::.....:|.  .||...:..:|:..|   .|:..|:.:|..:  |.::.|:  |||      :
Human   380 RLVEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGEDQEV--ELVVDYI--SKEVNEIMVK 440

  Fly    57 KALEQALKGTASSCEDIPIVIGGKEYKTPEVRYQVMPHDHQHKLASFYYADKKLIEKAIKTAVET 121
            ...:..:.|..:..:|      ||.|.|      :.|.|.. .:....||....::||:..|.:.
Human   441 MPYQCFINGQFTDADD------GKTYDT------INPTDGS-TICKVSYASLADVDKAVAAAKDA 492

  Fly   122 --QPKWDRVSIADRLKIWEKAADL-------MATTYRQDLNAATMLGQSKTAIQAEIDSAAELID 177
              ..:|.|::..:|.::..:.|||       :||....|..|...|     |::..|..:.:.. 
Human   493 FENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTL-----ALKTHIGMSVQTF- 551

  Fly   178 FIRMNAYFLKEVTKYQ----PISE-----NIKVTKNSLRYRGIDGFIAAVSPFNFTAIGGNLSYT 233
                 .||.....|.|    ||::     |:..||....     |..|.:.|:|:          
Human   552 -----RYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPL-----GVCAIIIPWNY---------- 596

  Fly   234 PALM-----------GNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITAS 287
            |.:|           ||.::.||:....|:.....::..:||.|.||:|.:|..|.:.|..::..
Human   597 PLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEH 661

  Fly   288 PHLAGINFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAF 352
            |.:..:.||||.|...::.|....:     |..:::.|.|||:...|....:::..|...:.:.|
Human   662 PDIRKLGFTGSTPIGKQIMKSCAVS-----NLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVF 721

  Fly   353 EYCGQKCSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHA 417
            ...|:.|.|..|::|.||:..:....:|.|..|:||||..|.|:...........:::..|.|..
Human   722 FNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETG 786

  Fly   418 KKSPNLEILAGGTYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDLLETMKLVHT 482
            .|. ...::.||......|:|:.||:....:....:..||.|||::.|..::..|:...::..: 
Human   787 VKE-GATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRAN- 849

  Fly   483 STKFALTGAVFGQDEDFVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAG 543
            ||::.|...||.:|.:  |......|:.||..:||..:...|..  ||||.:.||.....|
Human   850 STEYGLASGVFTRDIN--KAMYVSEKLEAGTVFINTYNKTDVAA--PFGGVKQSGFGKDLG 906

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
P5CDh1NP_649368.2 ALDH_F4-17_P5CDH 41..563 CDD:143441 127/538 (24%)
ALDH1L2NP_001029345.2 Hydrolase domain. /evidence=ECO:0000250|UniProtKB:P28037 23..331
FMT_core_FDH_N 23..225 CDD:187716
FDH_Hydrolase_C 228..327 CDD:187731
PP-binding 346..>390 CDD:425746 1/9 (11%)
Aldehyde dehydrogenase domain. /evidence=ECO:0000250|UniProtKB:P28037 438..923 122/519 (24%)
ALDH_F1L_FTFDH 439..923 CDD:143458 122/518 (24%)
Blue background indicates that the domain is not in the aligned region.

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