DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh1 and aldh1a2

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_571925.1	Gene:	aldh1a2 / 116713	ZFINID:	ZDB-GENE-011010-3	Length:	518	Species:	Danio rerio

Alignment Length:	506	Identity:	135/506 - (26%)
Similarity:	221/506 - (43%)	Gaps:	89/506 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 PEVRY-QVMPHDHQH-----------------KLASFYYADKKLIEKAI---KTAVETQPKWDRV 128
            ||::| ::..::..|                 |:.....|||..::||:   ::|......|.::
Zfish    33 PEIKYTKIFINNEWHDSVSGKVFPTYNPATGEKICDVQEADKADVDKAVQAARSAFSLGSVWRKM 97

  Fly   129 SIADRLKIWEKAADLMATTYRQDLNAATM--LGQSKTAIQAEIDSAAELIDFIRMNAYFLKEV-- 189
            ..::|.|:..|.|||:.   |.....||:  |...|..:.........:|...|..|.:..::
Zfish    98 DASERGKLLFKLADLVE---RDSAYLATLESLDSGKPFLPCFFVDLQGIIKTFRYYAGWADKIHG 159

  Fly   190 ------------TKYQPISENIKVTKNSLRYRGIDGFIAAVSPFNFTAIGGNLSYTPAL-MGNGV 241
                        |:::||                 |....:.|:||..:.......||| .||.|
Zfish   160 STIPIDGEFFTLTRHEPI-----------------GVCGQIIPWNFPLVMTAWKLGPALSCGNTV 207

  Fly   242 LWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAGINFTGSVPTFNRLW 306
            :.||::...|:...:..:::|||.|.||||.:|..||..|..|::...:..:.||||......:.
Zfish   208 VLKPAEQTPLTCLYLGALIKEAGFPPGVVNILPGYGPTAGAAISSHMGIDKVAFTGSTEVGKLIQ 272

  Fly   307 KQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQKCSACSRMYVPESL 371
            :..|.:     |..|:|.|.|||:.:.|.|.||.|..:....:..|...||.|:|.||::|.|.:
Zfish   273 EAAGKS-----NLKRVTLELGGKSPNIIFADADFELALEQAHQGVFFNNGQCCTAGSRIFVEEPI 332

  Fly   372 WPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRI-----TGYIEHAKKSPNLEILAGGTY 431
            :.:.....|..|.:.|:|:..|.::.....:.::..:|:     :|..|.||    ||  .||..
Zfish   333 YDEFVRRSVERAQRRKVGNPFDPTTEHGPQVSEEQQRRVLELIQSGITEGAK----LE--CGGKA 391

  Fly   432 SDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKE-SDLLETMKLVHTSTKFALTGAVFGQ 495
            ..:||:||.||:..:.....||..|||||||..|..:|. .:::|..    .:|::.|..|||.:
Zfish   392 PATKGFFVEPTVFSNVKDHMRIAKEEIFGPVQQIMKFKTIEEVIERA----NNTEYGLAAAVFTR 452

  Fly   496 DED---FVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAG 543
            |..   .:..|:|     ||..:||..:..|.  |.||||.:|||...:.|
Zfish   453 DISKAMTISAAVQ-----AGTVWINCYNAMSC--QCPFGGFKMSGNGRELG 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	135/506 (27%)
aldh1a2	NP_571925.1	ALDH_F1AB_F2_RALDH1	32..512	CDD:143459	135/506 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810