DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment P5CDh1 and ALDH1L1

DIOPT Version :9

Sequence 1:NP_001189159.1 Gene:P5CDh1 / 40434 FlyBaseID:FBgn0037138 Length:574 Species:Drosophila melanogaster
Sequence 2:NP_001257293.1 Gene:ALDH1L1 / 10840 HGNCID:3978 Length:912 Species:Homo sapiens


Alignment Length:603 Identity:147/603 - (24%)
Similarity:247/603 - (40%) Gaps:89/603 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLRMMRSSSSRCSSLQ---QSLLKSSTRCLGSVIPDL--KLKDFPIANEPILGYLKDSKERKALE 60
            ::|::......|..|:   :.:..:||  .|..|..|  ||:......|..:.|::.:..::.:.
Human   367 VVRLVEEVKELCDGLELENEDVYMAST--FGDFIQLLVRKLRGDDEEGECSIDYVEMAVNKRTVR 429

  Fly    61 QALKGTASSCEDIPIVIGGKEY------KTPEVRYQVMPHDH----QHKLASFYYADKKLIEKAI 115
            ...:          :.||| |:      ||.|.   :.|.|.    |..||.....||.:  .|.
Human   430 MPHQ----------LFIGG-EFVDAEGAKTSET---INPTDGSVICQVSLAQVTDVDKAV--AAA 478

  Fly   116 KTAVETQPKWDRVSIADRLKIWEKAADLM-------ATTYRQDLNAATMLGQSKTAIQAEIDSAA 173
            |.|.| ..:|.::|..||.::..:.||||       ||....|..|...|     |::..:..: 
Human   479 KDAFE-NGRWGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTL-----ALKTHVGMS- 536

  Fly   174 ELIDFIRMNAYFLKEVTKYQ----PISE---NIKVTKNSLRYRGIDGFIAAVSPFNFTAIGGNLS 231
                 |:...||.....|.|    ||::   |..:|.......|:.|.|.   |:|:..:  .||
Human   537 -----IQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIII---PWNYPLM--MLS 591

  Fly   232 YTPA---LMGNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAGI 293
            :..|   ..||.|:.||:....|:.....::..:||:|.||||.:|..|.:.|..::..|.:..|
Human   592 WKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKI 656

  Fly   294 NFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQK 358
            .||||......:.|....:     |..:::.|.|||:...|.|..|:...|...:.|.|...|:.
Human   657 GFTGSTEVGKHIMKSCAIS-----NVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGEN 716

  Fly   359 CSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHAKKSPNL 423
            |.|..|::|.:|:..:....:|.|..|:|:|:..|..:............::..|.:|..|. ..
Human   717 CIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKE-GA 780

  Fly   424 EILAGGTYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDLLETMKLVHTSTKFAL 488
            .::.||......|:|..||:....:....|..||.||||:.|..:.:.||...:...: :|:|.|
Human   781 TLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRAN-ATEFGL 844

  Fly   489 TGAVFGQDEDFVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAGGPHYILRWTS 553
            ...||.:|.:  |......|:.||..::|..:...|..  ||||.:.||.....|          
Human   845 ASGVFTRDIN--KALYVSDKLQAGTVFVNTYNKTDVAA--PFGGFKQSGFGKDLG---------- 895

  Fly   554 PQSIKETFVPLRDVNYPY 571
             ::....::.::.|.:.|
Human   896 -EAALNEYLRVKTVTFEY 912

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
P5CDh1NP_001189159.1 ALDH_F4-17_P5CDH 41..563 CDD:143441 135/548 (25%)
ALDH1L1NP_001257293.1 Fmt 10..319 CDD:223301
FMT_core_FDH_N 11..213 CDD:187716
FDH_Hydrolase_C 216..316 CDD:187731
PP-binding 335..401 CDD:278949 7/35 (20%)
ALDH_F1L_FTFDH 427..912 CDD:143458 134/539 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1012
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.