DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P5CDh1 and aldh1b1

DIOPT Version :9

Sequence 1:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	XP_004910950.1	Gene:	aldh1b1 / 100498540	XenbaseID:	XB-GENE-1013740	Length:	517	Species:	Xenopus tropicalis

Alignment Length:	565	Identity:	149/565 - (26%)
Similarity:	243/565 - (43%)	Gaps:	95/565 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MMRSSSSR-CSSLQQSLLKSSTRCLGSVIPDLKLKDFPIANEPILGYLK---DSKERKALEQALK 64
            |.||.|.. ..::.|...:.||    ::||.      |::| |.:.|.|   :::.|.|
Frog     1 MQRSFSHHYIGTIWQMGARFST----AIIPK------PLSN-PEVFYTKLFINNEWRDA------ 48

  Fly    65 GTASSCEDIPIVIGGKEYKTPE-VRYQVMPHDHQHKLASFYYADKKLIEKAIKTAVETQPK---W 125
                        :.|:.:.|.: ...:|:.|..:        |||..|:.|:|.|.|...:   |
Frog    49 ------------VSGRRFPTVDPCTGEVITHVAE--------ADKADIDAAVKAAREAFKQGSPW 93

  Fly   126 DRVSIADRLKIWEKAADLMATTYRQDLNAATMLGQSKTAIQAEIDSAAELIDFIRMNAYFLKEV- 189
            ..:..:.|.::..:.|||:........:..||......|....|| .:.::...|..|.|..:|
Frog    94 RSMDASQRGQLLHRLADLIERDKIYLASLETMDNGKPFADSFAID-LSTVVKVYRYYAGFADKVH 157

  Fly   190 -------------TKYQPISENIKVTKNSLRYRGIDGFIAAVSPFNFTAIGGNLSYTPAL-MGNG 240
                         |:::|:                 |....:.|:||..:.......||| .||.
Frog   158 GKTIPLDGNYFCYTRHEPV-----------------GVCGQIIPWNFPLVMQGWKLGPALATGNT 205

  Fly   241 VLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAGINFTGSVPTFNRL 305
            |:.|.::...||...|..:::|||.|.||||.:...||..|..:.....:..|.||||......:
Frog   206 VVMKVAEQTPLSALYIASLIKEAGYPPGVVNILTGFGPTAGAALAQHMDVDKIAFTGSTEVGRLI 270

  Fly   306 WKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQKCSACSRMYVPES 370
            .|..|:     .|..|:|.|.|||:...:.|.||:|..|.....:.|...||.|:|.||.:|.|:
Frog   271 QKAAGS-----TNLKRVTLELGGKSPCIVMADADLEQAVEQCHEALFFNMGQCCAAGSRTFVEEN 330

  Fly   371 LWPQIKEGLVCEAAKL-KIGDVQDFSSFTSAVIDDKAFKRITGYIEHAKKSPNLEILAGGTYSDS 434
            ::.:..|..| |.||| |:|:..|..:.....|:.:.|.:|.|||: :.|:...:::.||.....
Frog   331 VYDEFLERTV-EKAKLRKVGNPFDLDTKHGPQINKEQFDKILGYIK-SGKTEGAKLMCGGERYGD 393

  Fly   435 KGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKE-SDLLETMKLVHTSTKFALTGAVFGQDED 498
            ||:|:.||:..:.....:|..|||||||..::.:|. .:::|..    .:|.:.|...:|.:|.|
Frog   394 KGFFIKPTVFANVQDNMKIAREEIFGPVQPVFKFKSIKEVIERA----NNTSYGLAAGIFTRDLD 454

  Fly   499 FVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAG 543
              |..|....:.||..::|  :...|..|.||||.:.||...:.|
Frog   455 --KAMLLTQALRAGTVWVN--TYNIVTCQTPFGGFKESGNGRELG 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	139/527 (26%)
aldh1b1	XP_004910950.1	ALDH_F1AB_F2_RALDH1	31..511	CDD:143459	139/525 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910