DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nopp140 and Nolc1

DIOPT Version :9

Sequence 1:	NP_001262195.1	Gene:	Nopp140 / 40433	FlyBaseID:	FBgn0037137	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001034441.1	Gene:	Nolc1 / 70769	MGIID:	1918019	Length:	702	Species:	Mus musculus

Alignment Length:	813	Identity:	280/813 - (34%)
Similarity:	347/813 - (42%)	Gaps:	265/813 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVLEYLQSKDKNLAKVFQQKTKAASVAKSSPKLSEILQFY------QTKSPK-KI----PAIK-- 62
            :||.:|  :|..|::|..:..||....:.....|.:|..|      .||:|| |:    |..|
Mouse    17 LVLRFL--RDSQLSEVASKFAKATGATQQDANASSLLDIYSFWLNRSTKAPKVKLQSNGPVTKKA 79

  Fly    63 ---ATAGDSSEDSDSDSESDAAPKKPATAPALTNGKAVKKAASSTSEDSDSEEEKKPAAKATPAK 124
               .::.||||||..|.:..|            .|...:|||:.....|..:...|.||||:.:
Mouse    80 KKETSSSDSSEDSSEDEDKKA------------QGLPTQKAAAQVKRASVPQHAGKAAAKASES- 131

  Fly   125 AVGKKAKSSSEDSSSEEEAPKKAAPVK----APPAKAA--PAKKVESSSEDSSSEEEPAKPAVKA 183
                   ||||:||.|||..||..||:    .|.|||.  ||||.|||..||.|:
Mouse   132 -------SSSEESSEEEEEDKKKKPVQQKAAKPQAKAVRPPAKKAESSESDSDSD---------- 179

  Fly   184 TTTKVAPAKKADSSSEESSSDEETKPAAKPVAKAAPAKKAASSSEESDSDDEPAAKKPAVQPAAK 248
                           .:|||:|||....||  |||.|.||.:.:|          .||.....|:
Mouse   180 ---------------SDSSSEEETPQTQKP--KAAVAAKAQTKAE----------AKPGTPAKAQ 217

  Fly   249 PA---PKAAASSSEDSSSE--EEVKPAAKSAAKLAPAKKGASSSDDSSSEDEAPKKAATLAKPIS 308
            |.   .|||||||..|||:  ||.|.||      ||.||            ..|||......|:.
Mouse   218 PKVANGKAAASSSSSSSSDDSEEEKKAA------APPKK------------TVPKKQVVAKAPVK 264

  Fly   309 -KAAPTKKADSSTEDSSSEDD------APKKVAPAKATPAKAIPAKKAASSDDSSSEEEAPKKAA 366
             .||||:|: ||:||||||::      ..||..|..:.|..::|..|      .|...:||||||
Mouse   265 VAAAPTQKS-SSSEDSSSEEEEGQRQPMKKKAGPYSSVPPPSVPLPK------KSPGTQAPKKAA 322

  Fly   367 PANATPARAPPAKKA-ASSDDSSSEEEAPKKAAPAKA----TPAKATPAKKAA-----SSDDSSS 421
                  |:..||..: .|||||.|..|..|| .|||.    |||||.|.||.|     |||..||
Mouse   323 ------AQTQPADSSDDSSDDSDSSSEEEKK-PPAKTVVSKTPAKAAPVKKKAESSSDSSDSDSS 380

  Fly   422 EEEA----------------PKKAAAPAKATP-----------AKKAKSSS---EDSDSDEEEAP 456
            |:||                ||.:||.|..||           ::||.|||   |.|.|:||||.
Mouse   381 EDEAPAKPVSTTKSPKPAVTPKPSAAKAVTTPKQPAGSNQKPQSRKADSSSSEEESSSSEEEEAS 445

  Fly   457 KK----PAAKAVAKAASSEDSDSSEDEKPAKAAPKALAKSAKAASSDSDDSSDEE---TPAVKPA 514
            ||    |.||..||||            |||.||:|...|    |||||.||.||   ||  ||.
Mouse   446 KKSATTPKAKVTAKAA------------PAKQAPQAAGDS----SSDSDSSSSEEEEKTP--KPP 492

  Fly   515 VKK--------TAAPAKKAD-------SSSDESDSGEESGEVKPNSAT--------NG-----NE 551
            .||        |.||.|||:       |||...||.||..:.||.:.|        ||     |.
Mouse   493 AKKKAAGGAVSTPAPGKKAEAKSSSSSSSSSSEDSSEEEKKKKPKATTPKIQASKANGTPASLNG 557

  Fly   552 KTAQKRKFSGGDQDEATPNKKYNNFVKSGEQQKN------DFTSTPN---------NTFSRNHNM 601
            |.|::.:..  :::|.|..||.....|.|..:|.      |..:||.         |||.:...
Mouse   558 KAAKESEEE--EEEEETEEKKKAAGTKPGSGKKRKQNETADEATTPQAKKVKLETPNTFPKRKK- 619

  Fly   602 NNSGGGSGRRSPFRRVRTEDVVVDSRVQDMSFEAKENDFKKHNNGRGGRGGSGFSGRPDRSTWET 666
                |.....|||||||.|::.|||||.|.||:||             ||.:|..|  :|:. :.
Mouse   620 ----GERRASSPFRRVREEEIEVDSRVADNSFDAK-------------RGAAGDWG--ERAN-QV 664

  Fly   667 NKFNGEGGGDGGGFKKIGDRKSFGGFDNNQRGG 699
            .||.     .|..|:....:|..|.:    |||
Mouse   665 LKFT-----KGKSFRHEKTKKKRGSY----RGG 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nopp140	NP_001262195.1	None
Nolc1	NP_001034441.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..635		242/683 (35%)
		Nuclear localization signal. /evidence=ECO:0000255	69..83		2/13 (15%)
		11 X 12 AA approximate repeats of an acidic serine cluster. /evidence=ECO:0000250\|UniProtKB:Q14978	85..566		216/587 (37%)
		Interaction with RPA194. /evidence=ECO:0000250\|UniProtKB:Q14978	215..390		83/206 (40%)
		Nuclear localization signal. /evidence=ECO:0000255	392..590		78/217 (36%)
		Nuclear localization signal. /evidence=ECO:0000255	604..620		3/20 (15%)
		SRP40_C	627..693	CDD:309939	31/87 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2992
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004782
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23216
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1974
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030