DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nopp140 and nolc1

DIOPT Version :9

Sequence 1:	NP_001262195.1	Gene:	Nopp140 / 40433	FlyBaseID:	FBgn0037137	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001243581.1	Gene:	nolc1 / 561131	ZFINID:	ZDB-GENE-030131-6349	Length:	1001	Species:	Danio rerio

Alignment Length:	1028	Identity:	355/1028 - (34%)
Similarity:	432/1028 - (42%)	Gaps:	404/1028 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQSKDKNLAKVFQQKTKAASVAKSSPKLSEILQFYQTKSP--KKIPAIKATAG------------ 66
            :::|....||.|.::.|.....::...|.:|..|: .|||  ||..|:  |:|
Zfish    20 VENKFAKAAKEFLRQAKVKPQDQNEDSLMDIFNFW-VKSPETKKRKAV--TSGPAAVNGPSAKKA 81

  Fly    67 ----DSSEDSDSDSESDAA-------------PKKPAT-----------------APALTNGK-- 95
                |||...||.||.:.|             |||||.                 |||.|..|
Zfish    82 KKDADSSSSEDSSSEEEQAAPAKKAVQVKAPPPKKPAAVATKESSSEDSSDSEDEAPAKTTAKKP 146

  Fly    96 ------------AVKKAASSTSEDSDSEEE--KKPA-----------AKATPAKAVGKKAKSSSE 135
                        |.||..||:||:||||||  |.||           ..:||..|..||..||||
Zfish   147 AAVKAAVQPAAAARKKDTSSSSEESDSEEEPSKTPAKVVKPVTGTPKTVSTPVSAAQKKQDSSSE 211

  Fly   136 DSS--SEEEAPKKAA-----PVKA-PPAK------------------AAPAKKVE---------- 164
            |||  ||:|.|.|:|     |||. ||||                  |.|:||.:
Zfish   212 DSSSDSEDEPPAKSAVKAAVPVKTPPPAKPAAPAVSSSDDSSSDEEDAPPSKKPKTGQFSAVPPP 276

  Fly   165 -------------------------------SSSEDSSSEEEPAKPAVKA----------TTTKV 188
                                           |.|.|||||:|..||||||          ..|||
Zfish   277 GTLTAQAPVKTPAASVKTVTPKAAAKNDSSSSDSSDSSSEDEAKKPAVKAAPAKAAPAKKAPTKV 341

  Fly   189 APAKKADSSSEESSS--DEETKPAAKPV----------------AKAAPAK-------KAASSSE 228
            |||:|.||||.:|||  ||.||||.|..                |||||||       .::||||
Zfish   342 APAQKKDSSSSDSSSSEDEATKPAIKVTPAKAASAKSTPAKAAQAKAAPAKVTPAAEESSSSSSE 406

  Fly   229 ESDSDD-EPAAKKPAVQPAAK------------PAPKAAASSSEDSSSEEEVKPA----AKSA-- 274
            ||:.:. :||||....:.|||            ||.|.::.||.||..:|...||    ||:|
Zfish   407 ESEEESKKPAAKVAPGKAAAKRAPPKKTPAKVTPAAKESSPSSSDSEEDEPPTPAKATPAKAAPA 471

  Fly   275 ---------AKLAPAKKGASSSDDS-SSEDEAPKKAATLAKPISKAAP-TKKADSS--TEDSSSE 326
                     ||.|||||..|||.|| |||||||.|.|..:||:|...| .|.|:||  ::.||.|
Zfish   472 KATPAKATPAKAAPAKKDDSSSSDSESSEDEAPAKPAATSKPVSTPKPGAKPAESSSASDSSSDE 536

  Fly   327 DDAPK---------KVAPAKATPAKAI--PAKKAASSDDSSSEEEAPKKAA--------PANATP 372
            |:.|:         |.||||...||..  ||:.::||.||||:||..||.|        ||..||
Zfish   537 DEGPQKKPVTTPVSKPAPAKPPAAKTTNKPAESSSSSSDSSSDEEPKKKPATTPVSKPTPAKPTP 601

  Fly   373 ARAPPAKKAASSDDSSSEEE--APKKAA--PAK---ATPAKATPAKKAA--SSD-DSSSEEEAPK 427
            ......|:|.||.||||:||  ..||||  ||.   ||.||.|||.|.|  ||| ||||:|||.|
Zfish   602 TVKTTNKQAESSSDSSSDEEDKPQKKAATTPASKPVATSAKTTPAAKPAESSSDSDSSSDEEAQK 666

  Fly   428 KAAAPA---KATPAK---KAKSSSEDSDSDEEEAP-------------KKPAA---------KAV 464
            |...|.   .|||||   ||..||.||...|:|.|             |.|||         |..
Zfish   667 KTTTPVPSKPATPAKPAAKAAESSSDSSDSEDETPAAKTAKPAAATATKSPAAASKPPVSASKPA 731

  Fly   465 AKAASSEDSDSSEDEKPA------KAAPKAL-----AKSAKAASSDSDDSSDEETPA----VKPA 514
            |:::||:...||||||.|      |||||..     ||.|:::||:|.||||.||.|    .||.
Zfish   732 AESSSSDSDSSSEDEKQAKTTVTPKAAPKPAVTPVNAKKAESSSSESSDSSDSETEAKKTPAKPV 796

  Fly   515 V------------------KKTAAPAKKADSSSD------------------------------- 530
            |                  ||||..:..:|||||
Zfish   797 VANGKPVTKTPTSAAKTPAKKTAESSSSSDSSSDEEEPSKTPATKTPPATKTPPATKTPPATKTP 861

  Fly   531 ------------ESDSGEESGEVKPN-SATNGNEKTAQKRKFSGGDQDEATP-NKKYNNFVKSGE 581
                        ||.|.|||.|.:.. :||||.: :|:|          ||| |||.
Zfish   862 PATKKQAAEAKAESSSSEESSEEEETPAATNGTQ-SAKK----------ATPKNKKI-------- 907

  Fly   582 QQKNDFTSTPNNTFSRNHNMNNSGGGSGRRSPFRRVRTEDVVVDSRVQDMSFEAKENDFKKHNNG 646
                 .|||| .||.|....:::       :||||:|.|||.||.|::|.||:||
Zfish   908 -----ATSTP-QTFPRTKQKDSN-------APFRRIREEDVEVDPRLKDNSFDAK---------- 949

  Fly   647 RGGRGGSGFSGRPDRSTWETNKFNGEGGGDGGGFKKIGDRKSFGGFDNNQRGG 699
               .|.:|..|:...:..:..|        |..|:....:|..|.:    |||
Zfish   950 ---MGANGDWGQKANNVLKFTK--------GKSFRHEKTKKKRGSY----RGG 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nopp140	NP_001262195.1	None
nolc1	NP_001243581.1	SRP40_C	926..992	CDD:282829	27/87 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2992
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	304	1.000	Inparanoid score	I2637
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004782
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104928
Panther	1	1.100	-	-	LDO	PTHR23216
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1974
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.980