DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7148 and fbxl-1

DIOPT Version :9

Sequence 1:NP_649366.1 Gene:CG7148 / 40432 FlyBaseID:FBgn0046301 Length:454 Species:Drosophila melanogaster
Sequence 2:NP_741248.1 Gene:fbxl-1 / 3564805 WormBaseID:WBGene00015350 Length:466 Species:Caenorhabditis elegans


Alignment Length:429 Identity:88/429 - (20%)
Similarity:142/429 - (33%) Gaps:147/429 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 QLDDDCLAEIFDRLQDLPSEV-----SFART---CRRVQYICLSKWRTSHAYEQLDLEKWRVLLP 67
            |:|:..:..:      ||.||     ||..|   ||..| :|.| |    :...||...|:    
 Worm    50 QVDNSLINRV------LPKEVLLKVFSFLDTKALCRSAQ-VCRS-W----SILALDGSNWQ---- 98

  Fly    68 NHEDLVYFLTQMRPYI-----REMGGSSCLCSILKDL-----DEMHIAELPMVTSFYYDPDGVDC 122
             ..||..|...::..:     |..||      .||:|     :.:|.:.|...||...:.:.:..
 Worm    99 -RVDLFTFQRDVKTAVVENLARRCGG------FLKELSLKGCENVHDSALRTFTSRCPNLEHLSL 156

  Fly   123 Y----PTNRSIRKLARLLPGLKKLRLTTPIDGRYLSNFQHLQELHLYEDQHKAFELQQKYLDEVC 183
            |    .|:.|...|                 |||.....:|.    .|:.....:...||:.:.|
 Worm   157 YRCKRVTDASCENL-----------------GRYCHKLNYLN----LENCSSITDRAMKYIGDGC 200

  Fly   184 RTLHDLRVLDIRTYDMIS----KLQLGNC-------LQSFKNLTD-------------LKLNLAT 224
               .:|..|:|...|.|.    ::.|.||       |:..:.||:             .||||..
 Worm   201 ---PNLSYLNISWCDAIQDRGVQIILSNCKSLDTLILRGCEGLTENVFGSVEAHMGAIKKLNLLQ 262

  Fly   225 LKPILPAVLE-----LPSLRKLVVLLDNEWHIPPLVSPDSYDHKIREVSEFYEIMAFKAKDIVGF 284
            ...:....::     ..:|..|.:...|:.....|||...:.|.::       ::......::| 
 Worm   263 CFQLTDITVQNIANGATALEYLCMSNCNQISDRSLVSLGQHSHNLK-------VLELSGCTLLG- 319

  Fly   285 AVDGYYMPLEPGWDEKLPIWTHRRLKRLAI--CSWTHSADYLKRYTCMTELQLLCVRNWNDLSDE 347
              |..::||..|.         |:|:||.:  ||.                          :||.
 Worm   320 --DNGFIPLARGC---------RQLERLDMEDCSL--------------------------ISDH 347

  Fly   348 ILLEFVELCPRLEHLDVSYCRNLTPTFLPRALSILKRRE 386
            .:......|..|..|.:|:|..:|...:....|  |.||
 Worm   348 TINSLANNCTALRELSLSHCELITDESIQNLAS--KHRE 384

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7148NP_649366.1 leucine-rich repeat 333..358 CDD:275381 3/24 (13%)
fbxl-1NP_741248.1 F-box-like 60..101 CDD:372399 16/51 (31%)
AMN1 <121..268 CDD:187754 36/176 (20%)
leucine-rich repeat 125..150 CDD:275381 7/24 (29%)
leucine-rich repeat 151..176 CDD:275381 7/41 (17%)
leucine-rich repeat 177..202 CDD:275381 5/31 (16%)
leucine-rich repeat 203..228 CDD:275381 8/24 (33%)
leucine-rich repeat 229..280 CDD:275381 7/50 (14%)
AMN1 <281..440 CDD:187754 30/151 (20%)
leucine-rich repeat 281..306 CDD:275381 6/24 (25%)
leucine-rich repeat 307..332 CDD:275381 5/43 (12%)
leucine-rich repeat 333..357 CDD:275381 7/49 (14%)
leucine-rich repeat 359..384 CDD:275381 7/26 (27%)
leucine-rich repeat 386..409 CDD:275381
leucine-rich repeat 411..436 CDD:275381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1046098at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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