DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7148 and Fbxl12

DIOPT Version :9

Sequence 1:	NP_649366.1	Gene:	CG7148 / 40432	FlyBaseID:	FBgn0046301	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001273458.1	Gene:	Fbxl12 / 30843	MGIID:	1354738	Length:	349	Species:	Mus musculus

Alignment Length:	302	Identity:	79/302 - (26%)
Similarity:	116/302 - (38%)	Gaps:	81/302 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 IAELPMVTSFYYDPDGVDCYPTNRSIRKLARLLPGLKKLRLTTP-----------IDGRYLSNFQ 157
            :.|:|   |.:..|.|        |.|:.|||||....|....|           :|.|:|  ::
Mouse    17 VLEIP---SSWKKPKG--------SQRRGARLLPSQTILLPRNPGCRVCHRWKRLVDDRWL--WR 68

  Fly   158 HLQELHLYEDQHKA-FELQQKYLDEVCRTLHDLRVLDIRTYDMISKLQLGNCL-----QSFKNLT 216
            |: :|.||..:.|. :.|.::|:   ...|:.|| :....:......||...|     |...||.
Mouse    69 HV-DLTLYTMRPKVMWHLLRRYM---ASRLYSLR-MGGYLFSGSQAPQLSPALMRALGQKCPNLK 128

  Fly   217 DLKLNLATLK--PI--LPA---VLELPSLRKLVVLLDNEWHIPPLVSPDSYDHKIREVSEFYEIM 274
            .|.|::|.|.  ||  ||:   .|||.|....::.|..|.  .|.|.|      :.|......:.
Mouse   129 RLCLHVADLSMVPITSLPSTLRTLELHSCEISMIWLQKEQ--DPTVLP------LLECIVLDRVP 185

  Fly   275 AFKAKDIVG---------FAVDGYYMPLEPGWDEKLPIWTHRRLKRLAICSWTHSADYLKRYTCM 330
            ||:.:.:.|         ..:.|.|...|.|.|..|...::  |:||.:...|.|||
Mouse   186 AFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDASLQELSY--LQRLEVLGCTLSAD-------- 240

  Fly   331 TELQLLCV-RNWNDLSDEIL---------LEFVELCPRLEHL 362
              ..||.: |:..|:....|         |.|:|..|.||.|
Mouse   241 --STLLAISRHLRDVRKIRLTVGGLSAQGLVFLEGMPVLESL 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7148	NP_649366.1	leucine-rich repeat	333..358	CDD:275381	8/34 (24%)
Fbxl12	NP_001273458.1	F-box-like	<51..73	CDD:289689	4/24 (17%)
		leucine-rich repeat	127..148	CDD:275381	9/20 (45%)
		AMN1	144..>249	CDD:187754	30/124 (24%)
		leucine-rich repeat	149..175	CDD:275381	9/33 (27%)
		leucine-rich repeat	176..200	CDD:275381	4/23 (17%)
		leucine-rich repeat	201..226	CDD:275381	6/24 (25%)
		leucine-rich repeat	227..252	CDD:275381	10/34 (29%)
		leucine-rich repeat	253..276	CDD:275381	4/22 (18%)
		leucine-rich repeat	277..306	CDD:275381	3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1046098at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010