DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7148 and AMN1

DIOPT Version :9

Sequence 1:	NP_649366.1	Gene:	CG7148 / 40432	FlyBaseID:	FBgn0046301	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001106873.1	Gene:	AMN1 / 196394	HGNCID:	27281	Length:	258	Species:	Homo sapiens

Alignment Length:	214	Identity:	47/214 - (21%)
Similarity:	82/214 - (38%)	Gaps:	73/214 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 ISKLQLGNCLQSF-KNLTDLKLNLATLKPILPAVLELPSLRKLVVLLDNEWHIPPLVSPDSYDHK 263
            :|:| |..||..| ||::..   |..:||:.|.:.:     :|:.::..:..|.        |..
Human     7 VSQL-LDLCLWCFMKNISRY---LTDIKPLPPNIKD-----RLIKIMSMQGQIT--------DSN 54

  Fly   264 IREV-SEFYEIMAFKAKDIVGFAVDGYYMPLEPGWDEKLPIWTHRRLKRLAI------------- 314
            |.|: ....:.:..::.||...|:              |.:...|:||:|.:
Human    55 ISEILHPEVQTLDLRSCDISDAAL--------------LHLSNCRKLKKLNLNASKGNRVSVTSE 105

  Fly   315 --------CSWTHSADYLKRYTCMTELQLLCVRNWNDLSDEILLEFVELCPRLEHLDVSYCRNLT 371
                    ||:.|.|. |||  |       |     :|:||.::.....|..|:.:|:..|.::|
Human   106 GIKAVASSCSYLHEAS-LKR--C-------C-----NLTDEGVVALALNCQLLKIIDLGGCLSIT 155

  Fly   372 PTFLPRALSILKRREPFKQ 390
            ..    :|..|.:..||.|
Human   156 DV----SLHALGKNCPFLQ 170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7148	NP_649366.1	leucine-rich repeat	333..358	CDD:275381	5/24 (21%)
AMN1	NP_001106873.1	AMN1	37..257	CDD:187754	35/180 (19%)
		leucine-rich repeat	63..86	CDD:275381	4/36 (11%)
		leucine-rich repeat	87..116	CDD:275381	4/28 (14%)
		leucine-rich repeat	117..142	CDD:275381	11/39 (28%)
		leucine-rich repeat	143..168	CDD:275381	6/28 (21%)
		leucine-rich repeat	169..195	CDD:275381	1/2 (50%)
		leucine-rich repeat	196..221	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1046098at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010