DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7148 and FBXO39

DIOPT Version :9

Sequence 1:	NP_649366.1	Gene:	CG7148 / 40432	FlyBaseID:	FBgn0046301	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_694962.1	Gene:	FBXO39 / 162517	HGNCID:	28565	Length:	442	Species:	Homo sapiens

Alignment Length:	370	Identity:	75/370 - (20%)
Similarity:	128/370 - (34%)	Gaps:	113/370 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 CLSKWRT-----SHAYEQLDLEKWRVLLPNH--EDLVYFLTQM---RPYIREMGGSSCL---CSI 95
            ||||...     |..|.:||...||..:.:.  ..|.:||.:|   ..|:...|....:   |.|
Human   118 CLSKSNNRLKSLSIQYLELDRLVWRNSIRSSFISSLSFFLKKMGKRLDYLNLKGARLTVEQGCQI 182

  Fly    96 LKDLDEMH----IAELPMVTSFYYDPDGVDCYPTNRSIRKLARLLPGLKKLRLTTPIDGRYLSNF 156
            |..|..|.    |:||.:...|.:.   :..|.:           |..||.          :|.|
Human   183 LDSLSYMRNENVISELNIEDYFSHH---LAVYNS-----------PQFKKT----------MSTF 223

  Fly   157 QHLQELHLYEDQHKAFELQQKYLDEVCRTLHDLRVLDIR--TYDMISKLQLG-NCLQSFKNLTDL 218
            .:|..|:|..:.     :..:.|:.:|.....||.::|:  .:|...::..| :..:..:..|:|
Human   224 HNLVSLNLNYNC-----ISDELLENLCENASTLRTINIKCHVHDPHGQVIWGMSWAKLARQATNL 283

  Fly   219 KLNLATLKPILPAVLELPSLRKLVVLLDNEWHIPPLVSPDSYDHKIREVSEFYEIMAFKAKDIVG 283
            |:|.     ....:::...|.::::     ..||           ||.:|  .....|...|
Human   284 KVNF-----FFERIMKYERLARILL-----QEIP-----------IRSIS--LRSCYFSDPD--- 322

  Fly   284 FAVDGYYMPLEPGWDEKLPIWTHRRLKRLAICSWTHSADYLKRYTCMTELQLLCVRNWNDLSDEI 348
                   ..:.|...:.||.:.|.                |::.||...      .|...|.:|:
Human   323 -------CSMRPTLIDLLPTFRHT----------------LQKLTCEFN------NNHESLDEEL 358

  Fly   349 LLEFVELCPRLEH------LDVSYCRNLTPTFLPR--ALSILKRR 385
            .|..:. |.:|.:      ||||:...:..:...|  ||.:.|.|
Human   359 HLLIIS-CRKLFYFKIWAFLDVSFVERILKSQKERQCALRVFKAR 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7148	NP_649366.1	leucine-rich repeat	333..358	CDD:275381	5/24 (21%)
FBXO39	NP_694962.1	F-box-like	16..57	CDD:289689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1046098at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010