Protein Alignment eIF2A and Eif2a

DIOPT Version :10

• Sequence 1: NP_649365.1
• Gene: eIF2A / 40431
• FlyBaseID: FBgn0037135
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_001386747.1
• Gene: Eif2a / 502531
• RGDID: 1589591
• Length: 581
• Species: Rattus norvegicus
• Alignment Length: 638
• Identity: 241/638 - (37%)
• Similarity: 351/638 - (55%)
• Gaps: 77/638 - (12%)

  Fly    10 PTLAIRSSVAVELWSSAGSKQPFEHKPHLPREETKSSRSICFSSNGRYFAYSNGQEVKVLQASRD 74
            |.|.:|.|..:.:   ......|.....||||..|:.:...||.:|..||:|||::|.::
  Rat     6 PLLTVRGSEGLYM---VNGPPHFTESTVLPREPGKNCKVYTFSKDGTLFAWSNGEKVNII----- 62

  Fly    75 SAASWPVICVLPRPKAFYLQFSPRGSYLCTWEHYAITKDRPEGSPNLLVYEVATGVEVFAIVQKN 139
            :.|:..::.....|||..|:|||..:.|.||:.|..:||...|:|||.:|:|.||..:.:.:||.
  Rat    63 NVANKGLLHSFDLPKAVCLEFSPNNTVLATWQPYTTSKDGTAGTPNLQLYDVKTGTCLKSFIQKK 127

  Fly   140 QADWQPSWSADESIFALVVGGEALFYDLGEGAEKGFATTSRKIGGSRGGMLSLGPGNCPPFLAFY 204
            ..:|.||||.||.|.|..|..|..|::     ...|.|.:.|:...:....:|.||..|..:|.|
  Rat   128 MQNWCPSWSDDEIICARNVNNEVHFFE-----NNNFNTIANKLHLQKVNDFNLSPGTQPFKVAVY 187

  Fly   205 TPGAKGAPSMCKLYKYPAL-GQNQTVACKSFFQADRVEMLWNKRGSGLLLLTSTEVDKSGASYYG 268
            .||:|||||..:||:||.. |....:|.||||:||:|.|||||:.:.:|::.||:|||:||||||
  Rat   188 VPGSKGAPSFVRLYQYPNFAGPQAALANKSFFKADKVTMLWNKKATAVLVIASTDVDKTGASYYG 252

  Fly   269 NQAVHFMATKGDTCSVPLSKEGPVHCVKWSPKATEFVVVYGFMPSKAALYNLKCDVVFDFGEGPR 333
            .|.:|::||.|::..|.|.|.||::.|.|:|.:|||..||||||:||.::|||||.|||||.|||
  Rat   253 EQTLHYIATNGESAVVQLPKNGPIYDVAWNPSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPR 317

  Fly   334 NCAYFNPFGNLIALAGFGNLPGAVEVWDVSKREKLANLKCADTTVFEWHPNGEWFVTATTAPRLR 398
            |.|:::|.|:::.|||||||.|.:|||||...:.::....:|:|.|.|.|:||..:|||.|||||
  Rat   318 NAAFYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLR 382

  Fly   399 ISNGFKVYHYSGALLHETMWPQGQELLGIEWQQFADKTFSEPKITKAKHEGIKSSQPEASKK--- 460
            ::||:|::||:|:||::...|...||..:.||.|.|..|....||   ::.:.|..|....|
  Rat   383 VNNGYKIWHYTGSLLYKYDVPSNGELWQVSWQPFLDGIFPAKTIT---YQAVPSEVPSEEPKVAT 444

  Fly   461 AYTPPHLR-------LLKEGKNPEKYLPQPSI-PGLAPTAAAGGVNGNKRNNKNKQRSARKDVNV 517
            ||.||.||       .|.|.:.|:...|.||. ..|:.||..     |:|.::.|:.:.::..|
  Rat   445 AYRPPALRNKPVTSSKLHEEEPPQNMKPHPSSDKPLSKTALK-----NQRKHEAKKAAKQEARN- 503

  Fly   518 VNGGDADSAPTEVVDQAAPVARQSPVFVAAEERKPQHTPRQKYQPDNAADQPPNSYGQGHPNGQH 582
                  |.|||.|                     ||..||.......:.|
  Rat   504 ------DLAPTPV---------------------PQSAPRSTVTQSASGD--------------- 526

  Fly   583 ISDKERKIRSVAKKLSDIKKLKVRRSQGENLELNQLNKIKMEAQYLDELKALK 635
             .:.::||:::.|||..|::||.:.:.|:.||.|||.||:.|...|.||:.|:
  Rat   527 -PEVDKKIKNLKKKLKAIEQLKEQAAAGKQLEKNQLEKIQKETALLQELEDLE 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2A	NP_649365.1	COG5354	13..636	CDD:227657	239/635 (38%)
		eIF2A	232..418	CDD:462552	101/185 (55%)
		WD40 repeat	292..327	CDD:293791	20/34 (59%)
		WD40 repeat	334..371	CDD:293791	17/36 (47%)
		WD40 repeat	376..399	CDD:293791	13/22 (59%)
Eif2a	NP_001386747.1	COG5354	44..567	CDD:227657	226/584 (39%)
		eIF2A	216..411	CDD:462552	104/194 (54%)
		WD40 repeat	277..311	CDD:293791	20/33 (61%)
		WD40 repeat	318..352	CDD:293791	17/33 (52%)
		WD40 repeat	360..401	CDD:293791	22/40 (55%)