Protein Alignment eIF2A and Eif2a

DIOPT Version :10

• Sequence 1: NP_649365.1
• Gene: eIF2A / 40431
• FlyBaseID: FBgn0037135
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_001005509.1
• Gene: Eif2a / 229317
• MGIID: 1098684
• Length: 581
• Species: Mus musculus
• Alignment Length: 638
• Identity: 243/638 - (38%)
• Similarity: 355/638 - (55%)
• Gaps: 77/638 - (12%)

  Fly    10 PTLAIRSSVAVELWSSAGSKQPFEHKPHLPREETKSSRSICFSSNGRYFAYSNGQEVKVLQASRD 74
            |.|.:|.|..:.:   ......|.....||||..::.:...||.:|..||:|||::|.::
Mouse     6 PLLTVRGSEGLYM---VNGPPHFTESTVLPRESGRNCKVYTFSKDGTLFAWSNGEKVNII----- 62

  Fly    75 SAASWPVICVLPRPKAFYLQFSPRGSYLCTWEHYAITKDRPEGSPNLLVYEVATGVEVFAIVQKN 139
            :.|:..::.....|||..|:|||..:.|.||:.|..:||...|:|||.:|::.||..:.:.:||.
Mouse    63 NVANKGLLHSFDLPKAVCLEFSPNNTVLATWQPYTTSKDGTAGTPNLQLYDMKTGACLKSFIQKK 127

  Fly   140 QADWQPSWSADESIFALVVGGEALFYDLGEGAEKGFATTSRKIGGSRGGMLSLGPGNCPPFLAFY 204
            ..:|.||||.||.|.|..|..|..|::     ...|.|.:.|:...:....:|.||..|..:|.|
Mouse   128 MQNWCPSWSDDEIICARNVNNEVHFFE-----NNNFNTIANKLHLQKVNDFNLSPGTQPYKVAVY 187

  Fly   205 TPGAKGAPSMCKLYKYPAL-GQNQTVACKSFFQADRVEMLWNKRGSGLLLLTSTEVDKSGASYYG 268
            .||:|||||..:||:||.. |....:|.||||:||:|.|||||:.:.:|::.||||||:||||||
Mouse   188 VPGSKGAPSFVRLYQYPNFAGPQAALANKSFFKADKVTMLWNKKATAVLVIASTEVDKTGASYYG 252

  Fly   269 NQAVHFMATKGDTCSVPLSKEGPVHCVKWSPKATEFVVVYGFMPSKAALYNLKCDVVFDFGEGPR 333
            .|.:|::||.|::..|.|.|.||::.|.|:..:|||..||||||:||.::|||||.|||||.|||
Mouse   253 EQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPR 317

  Fly   334 NCAYFNPFGNLIALAGFGNLPGAVEVWDVSKREKLANLKCADTTVFEWHPNGEWFVTATTAPRLR 398
            |.|:::|.|:::.|||||||.|.:|||||...:.::....:|:|.|.|.|:||..:|||.|||||
Mouse   318 NAAFYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLR 382

  Fly   399 ISNGFKVYHYSGALLHETMWPQGQELLGIEWQQFADKTFSEPKITKAKHEGIKSSQPEASKK--- 460
            ::||:|::||:|:|||:...|...||..:.||.|.|..|....|   |::.:.|..|....|
Mouse   383 VNNGYKIWHYTGSLLHKYDVPSNGELWQVSWQPFLDGIFPAKTI---KYQAVPSEVPSEEPKVAT 444

  Fly   461 AYTPPHLR-------LLKEGKNPEKYLPQP-SIPGLAPTAAAGGVNGNKRNNKNKQRSARKDVNV 517
            ||.||.||       .|.|.:.|:...|.| |...|:.||..     |:|.::.| ::|:::..
Mouse   445 AYRPPALRNKPVTNSKLHEEEPPQNMKPHPGSDKPLSKTALK-----NQRKHEAK-KAAKQEAR- 502

  Fly   518 VNGGDADSAPTEVVDQAAPVARQSPVFVAAEERKPQHTPRQKYQPDNAADQPPNSYGQGHPNGQH 582
                 :|:|||.|                     ||..||      |...|.    ..|.|
Mouse   503 -----SDAAPTPV---------------------PQSAPR------NTVTQS----ASGDP---- 527

  Fly   583 ISDKERKIRSVAKKLSDIKKLKVRRSQGENLELNQLNKIKMEAQYLDELKALK 635
              :.::||:::.|||..|::||.:.:.|:.||.|||.||:.|...|.||:.|:
Mouse   528 --EVDKKIKNLKKKLKAIEQLKEQAAAGKQLEKNQLEKIQKETALLQELEDLE 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2A	NP_649365.1	COG5354	13..636	CDD:227657	241/635 (38%)
		eIF2A	232..418	CDD:462552	102/185 (55%)
		WD40 repeat	292..327	CDD:293791	19/34 (56%)
		WD40 repeat	334..371	CDD:293791	17/36 (47%)
		WD40 repeat	376..399	CDD:293791	13/22 (59%)
Eif2a	NP_001005509.1	COG5354	10..567	CDD:227657	236/621 (38%)
		WD 1	23..63		14/44 (32%)
		WD 2	125..163		16/42 (38%)
		eIF2A	216..411	CDD:462552	105/194 (54%)
		WD 3	356..401		24/44 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	432..533		35/149 (23%)